Gene Rs1205 Polymorphism is Not Associated with the Risk of Colorectal Cancer

Overview

Journal Biosci Rep

Specialty Cell Biology

Date 2017 Jul 15

PMID 28706007

Citations 6

Authors

Dilong Fang

Yu Ye

Affiliations

Soon will be listed here.

Abstract

The relationship between () gene rs1205 polymorphism and the risk of colorectal cancer (CRC) has been investigated previously. However, the results were conflicting. In the present study, we assessed whether gene rs1205 polymorphism was associated with the risk of CRC by meta-analysis. We searched in PubMed, Embase, and the CNKI databases. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Seven original studies involving 4,181 cases and 10,601 controls analyzed the association between gene rs1205 polymorphism and CRC risk. No significant association was found between gene rs1205 polymorphism and CRC risk in this meta-analysis. Sensitivity analysis did not draw different findings. Stratification analyses of ethnicity, type of cancer, and genotype method also did not obtain any association between gene rs1205 polymorphism and CRC risk. In conclusion, this meta-analysis indicates that gene rs1205 polymorphism was not associated with the risk of CRC.

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