Transcriptional Role of Androgen Receptor in the Expression of Long Non-coding RNA Sox2OT in Neurogenesis

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2017 Jul 14

PMID 28704421

Citations 12

Authors

Valentina Tosetti

Jenny Sassone

Anna L M Ferri

Michela Taiana

Gloria Bedini

Sara Nava

Greta Brenna

Chiara Di Resta

Davide Pareyson

Anna Maria Di Giulio

Stephana Carelli

Eugenio A Parati

Alfredo Gorio

Affiliations

Soon will be listed here.

Abstract

The complex architecture of adult brain derives from tightly regulated migration and differentiation of precursor cells generated during embryonic neurogenesis. Changes at transcriptional level of genes that regulate migration and differentiation may lead to neurodevelopmental disorders. Androgen receptor (AR) is a transcription factor that is already expressed during early embryonic days. However, AR role in the regulation of gene expression at early embryonic stage is yet to be determinate. Long non-coding RNA (lncRNA) Sox2 overlapping transcript (Sox2OT) plays a crucial role in gene expression control during development but its transcriptional regulation is still to be clearly defined. Here, using Bicalutamide in order to pharmacologically inactivated AR, we investigated whether AR participates in the regulation of the transcription of the lncRNASox2OTat early embryonic stage. We identified a new DNA binding region upstream of Sox2 locus containing three androgen response elements (ARE), and found that AR binds such a sequence in embryonic neural stem cells and in mouse embryonic brain. Our data suggest that through this binding, AR can promote the RNA polymerase II dependent transcription of Sox2OT. Our findings also suggest that AR participates in embryonic neurogenesis through transcriptional control of the long non-coding RNA Sox2OT.

Citing Articles

The emerging role of long non-coding RNA SOX2-OT in cancers and non-malignant diseases.

Yang J, Tan F, Chen Y, Li X, Yuan C J Physiol Biochem. 2024; .

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Long Noncoding RNA SOX2-OT: Regulations, Functions, and Roles on Mental Illnesses, Cancers, and Diabetic Complications.

Li P, Wang P, Gao S, Dong D Biomed Res Int. 2020; 2020:2901589.

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Knockdown of long non-coding RNA SOX2OT downregulates SOX2 to improve hippocampal neurogenesis and cognitive function in a mouse model of sepsis-associated encephalopathy.

Yin J, Shen Y, Si Y, Zhang Y, Du J, Hu X J Neuroinflammation. 2020; 17(1):320.

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