Understanding the Inguinal Sinus in Sheep (Ovis Aries)-Morphology, Secretion, and Expression of Progesterone, Estrogens, and Prolactin Receptors

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2017 Jul 14

PMID 28703772

Citations 1

Authors

Graca Alexandre-Pires

Catarina Martins

Antonio M Galvao

Margarida Miranda

Olga Silva

Dario Ligeiro

Telmo Nunes

Graca Ferreira-Dias

Affiliations

Soon will be listed here.

Abstract

Post-parturient behavior of mammalian females is essential for early parent-offspring contact. After delivery, lambs need to ingest colostrum for obtaining the related immunological protection, and early interactions between the mother and the lamb are crucial. Despite visual and auditory cues, olfactory cues are decisive in lamb orientation to the mammary gland. In sheep, the inguinal sinus is located bilaterally near the mammary gland as a skin pouch (IGS) that presents a gland that secretes a strong-smelling wax. Sheep IGS gland functions have many aspects under evaluation. The objective of the present study was to evaluate sheep IGS gland functional aspects and mRNA transcription and the protein expression of several hormone receptors, such as progesterone receptor (PGR), estrogen receptor 1 (ESR1), and 2 (ESR2) and prolactin receptor (PRLR) present. In addition, another aim was to achieve information about IGS ultrastructure and chemical compounds produced in this gland. All hormone receptors evaluated show expression in IGS during the estrous cycle (follicular/luteal phases), pregnancy, and the post-partum period. IGS secretion is rich in triterpenoids that totally differ from the surrounding skin. They might be essential substances for the development of an olfactory preference of newborns to their mothers.

Citing Articles

Molecular Pathways of Estrogen Receptor Action.

Pakdel F Int J Mol Sci. 2018; 19(9).

PMID: 30200344 PMC: 6164862. DOI: 10.3390/ijms19092591.

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