Chemoselective Ullmann Coupling at Room Temperature: a Facile Access to 2-aminobenzo[b]thiophenes

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2017 Jul 14

PMID 28702515

Citations 3

Authors

Manojkumar Janni

Annaram Thirupathi

Sahil Arora

S Peruncheralathan

Affiliations

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Abstract

Various functionalized 2-aminobenzo[b]thiophenes have been synthesized at room temperature by the Ullmann coupling reaction for the first time. The enantiospecific coupling reaction has been further demonstrated without loss of optical purity. The newly synthesized 2-anilino-3-cyano-benzo[b]thiophenes are transformed into 11-amino-benzothieno[2,3-b]quinolines in the presence of triflic acid.

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