Aberrant Long-Range Temporal Correlations in Depression Are Attenuated After Psychological Treatment

Overview

Journal Front Hum Neurosci

Specialty Neurology

Date 2017 Jul 14

PMID 28701943

Citations 6

Authors

Matti Gartner

Mona Irrmischer

Emilia Winnebeck

Maria Fissler

Julia M Huntenburg

Titus A Schroeter

Malek Bajbouj

Klaus Linkenkaer-Hansen

Vadim V Nikulin

Thorsten Barnhofer

Affiliations

Soon will be listed here.

Abstract

The spontaneous oscillatory activity in the human brain shows long-range temporal correlations (LRTC) that extend over time scales of seconds to minutes. Previous research has demonstrated aberrant LRTC in depressed patients; however, it is unknown whether the neuronal dynamics normalize after psychological treatment. In this study, we recorded EEG during eyes-closed rest in depressed patients ( = 71) and healthy controls ( = 25), and investigated the temporal dynamics in depressed patients at baseline, and after attending either a brief mindfulness training or a stress reduction training. Compared to the healthy controls, depressed patients showed stronger LRTC in theta oscillations (4-7 Hz) at baseline. Following the psychological interventions both groups of patients demonstrated reduced LRTC in the theta band. The reduction of theta LRTC differed marginally between the groups, and explorative analyses of separate groups revealed noteworthy topographic differences. A positive relationship between the changes in LRTC, and changes in depressive symptoms was observed in the mindfulness group. In summary, our data show that aberrant temporal dynamics of ongoing oscillations in depressive patients are attenuated after treatment, and thus may help uncover the mechanisms with which psychotherapeutic interventions affect the brain.

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