Analytical Techniques and Pharmacokinetics of Gastrodia Elata Blume and Its Constituents

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2017 Jul 13

PMID 28698450

Citations 11

Authors

Jinyi Wu

Bingchu Wu

Chunlan Tang

Jinshun Zhao

Affiliations

Soon will be listed here.

Abstract

Blume (), commonly called Tianma in Chinese, is an important and notable traditional Chinese medicine (TCM), which has been used in China as an anticonvulsant, analgesic, sedative, anti-asthma, anti-immune drug since ancient times. The aim of this review is to provide an overview of the abundant efforts of scientists in developing analytical techniques and performing pharmacokinetic studies of and its constituents, including sample pretreatment methods, analytical techniques, absorption, distribution, metabolism, excretion (ADME) and influence factors to its pharmacokinetics. Based on the reported pharmacokinetic property data of and its constituents, it is hoped that more studies will focus on the development of rapid and sensitive analytical techniques, discovering new therapeutic uses and understanding the specific in vivo mechanisms of action of and its constituents from the pharmacokinetic viewpoint in the near future. The present review discusses analytical techniques and pharmacokinetics of and its constituents reported from 1985 onwards.

Citing Articles

Effects of Three Kinds of Carbohydrate Pharmaceutical Excipients-Fructose, Lactose and Arabic Gum on Intestinal Absorption of Gastrodin through Glucose Transport Pathway in Rats.

Chen Z, Chen J, Wang L, Wang W, Zheng J, Wu S Pharm Res. 2024; 41(6):1201-1216.

PMID: 38834905 DOI: 10.1007/s11095-024-03720-3.

The preventive effect of Gastrodia elata Blume extract on vancomycin-induced acute kidney injury in rats.

Lee Y, Park Y, Lee H, Park H, Lee H, Kim G Lab Anim Res. 2024; 40(1):14.

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Effects of Nutraceutical Compositions Containing Rhizoma Gastrodiae or Lipoic Acid in an In Vitro Induced Neuropathic Pain Model.

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Neutral polysaccharide from Gastrodia elata alleviates cerebral ischemia-reperfusion injury by inhibiting ferroptosis-mediated neuroinflammation via the NRF2/HO-1 signaling pathway.

Zhang Y, Ye P, Zhu H, Gu L, Li Y, Feng S CNS Neurosci Ther. 2023; 30(3):e14456.

PMID: 37752806 PMC: 10916450. DOI: 10.1111/cns.14456.

Para‑hydroxybenzaldehyde against transient focal cerebral ischemia in rats via mitochondrial preservation.

Xiao T, Yang L, Chen P, Duan X Exp Ther Med. 2022; 24(6):716.

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