In Vitro Evaluation of the Inhibitory Activity of Thymoquinone in Combatting Candida Albicans in Denture Stomatitis Prevention

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2017 Jul 13

PMID 28698449

Citations 13

Authors

Ahmad M Al-Thobity

Khalifa S Al-Khalifa

Mohammed M Gad

Mohammed Al-Hariri

Aiman A Ali

Talal Alnassar

Affiliations

Soon will be listed here.

Abstract

adhesion and proliferation on denture bases may lead to denture stomatitis, which is a common and recurrent problem in denture wearers. The goal of this study was to assess the inhibitory effect of thymoquinone incorporated in the polymethyl methacrylate denture base material against . Eighty acrylic resin specimens were fabricated and divided into eight groups ( = 10) according to thymoquinone concentrations of 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, and 5% of acrylic powder. Two methods were used to evaluate the effect of thymoquinone on : the slide count and the serial dilution test. A multivariate analysis of variance (MANOVA) and the post-hoc Tukey's Honestly Significant Difference (HSD) test were performed to compare the difference of means between the observations taken at various intervals with baseline. The value was statistically significant at ≤0.05. According to the slide count and the serial dilution test, the mean number of adhered in the control group was 5436.9 ± 266 and 4691.4 ± 176.8; however, this number dramatically decreased to 0 ± 0 and 32.4 ± 1.7 in group 8 (concentration 5%). These results suggest that the incorporation of thymoquinone into the acrylic resin denture base material might be effective in preventing adhesion.

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