A Systematic Review of Reviews: Exploring the Relationship Between Obesity, Weight Loss and Health-related Quality of Life

Overview

Journal Clin Obes

Specialty Endocrinology

Date 2017 Jul 12

PMID 28695722

Citations 200

Authors

R L Kolotkin

J R Andersen

Affiliations

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Abstract

This is the first systematic review of reviews to assess the effect of obesity and weight loss on health-related quality of life (HRQoL). We identified 12 meta-analyses/systematic reviews published between January 2001 and July 2016. They addressed the following themes: (i) the relationship between weight/body mass index and HRQoL (baseline/pre-intervention; n = 2). (ii) HRQoL after weight loss (varied interventions and/or study design; n = 2). (iii) HRQoL after weight loss (randomized controlled trials only; n = 2). (iv) HRQoL after bariatric surgery (n = 6). We found that in all populations, obesity was associated with significantly lower generic and obesity-specific HRQoL. The relationship between weight loss and improved HRQoL was consistently demonstrated after bariatric surgery, perhaps due to a greater than average weight loss compared with other treatments. Improved HRQoL was evident after non-surgical weight loss, but was not consistently demonstrated, even in randomized controlled trials. This inconsistency may be attributed to variation in quality of reporting, assessment measures, study populations and weight-loss interventions. We recommend longer-term studies, using both generic and obesity-specific measures, which go beyond HRQoL in isolation to exploring mediators of HRQoL changes and interactions with other variables, such as comorbidities, fitness level and body image.

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References

Halperin F, Ding S, Simonson D, Panosian J, Goebel-Fabbri A, Wewalka M . Roux-en-Y gastric bypass surgery or lifestyle with intensive medical management in patients with type 2 diabetes: feasibility and 1-year results of a randomized clinical trial. JAMA Surg. 2014; 149(7):716-26. PMC: 4274782. DOI: 10.1001/jamasurg.2014.514. View

Warkentin L, Das D, Majumdar S, Johnson J, Padwal R . The effect of weight loss on health-related quality of life: systematic review and meta-analysis of randomized trials. Obes Rev. 2013; 15(3):169-82. DOI: 10.1111/obr.12113. View

Williamson D, Rejeski J, Lang W, Van Dorsten B, Fabricatore A, Toledo K . Impact of a weight management program on health-related quality of life in overweight adults with type 2 diabetes. Arch Intern Med. 2009; 169(2):163-71. PMC: 2705948. DOI: 10.1001/archinternmed.2008.544. View

Wolf A, Conaway M, Crowther J, Hazen K, Nadler J, Oneida B . Translating lifestyle intervention to practice in obese patients with type 2 diabetes: Improving Control with Activity and Nutrition (ICAN) study. Diabetes Care. 2004; 27(7):1570-6. DOI: 10.2337/diacare.27.7.1570. View

. Development of the World Health Organization WHOQOL-BREF quality of life assessment. The WHOQOL Group. Psychol Med. 1998; 28(3):551-8. DOI: 10.1017/s0033291798006667. View

Kurth T, Gaziano J, Berger K, Kase C, Rexrode K, Cook N . Body mass index and the risk of stroke in men. Arch Intern Med. 2002; 162(22):2557-62. DOI: 10.1001/archinte.162.22.2557. View

Raoof M, Naslund I, Rask E, Karlsson J, Sundbom M, Edholm D . Health-Related Quality-of-Life (HRQoL) on an Average of 12 Years After Gastric Bypass Surgery. Obes Surg. 2015; 25(7):1119-27. DOI: 10.1007/s11695-014-1513-6. View

Hachem A, Brennan L . Quality of Life Outcomes of Bariatric Surgery: A Systematic Review. Obes Surg. 2015; 26(2):395-409. DOI: 10.1007/s11695-015-1940-z. View

Carson T, Hidalgo B, Ard J, Affuso O . Dietary interventions and quality of life: a systematic review of the literature. J Nutr Educ Behav. 2013; 46(2):90-101. PMC: 3982833. DOI: 10.1016/j.jneb.2013.09.005. View

10.

Evangelista L, Heber D, Li Z, Bowerman S, Hamilton M, Fonarow G . Reduced body weight and adiposity with a high-protein diet improves functional status, lipid profiles, glycemic control, and quality of life in patients with heart failure: a feasibility study. J Cardiovasc Nurs. 2009; 24(3):207-15. PMC: 2905143. DOI: 10.1097/JCN.0b013e31819846b9. View

11.

Yancy Jr W, Almirall D, Maciejewski M, Kolotkin R, McDuffie J, Westman E . Effects of two weight-loss diets on health-related quality of life. Qual Life Res. 2009; 18(3):281-9. DOI: 10.1007/s11136-009-9444-8. View

12.

Adams T, Davidson L, Litwin S, Kolotkin R, LaMonte M, Pendleton R . Health benefits of gastric bypass surgery after 6 years. JAMA. 2012; 308(11):1122-31. PMC: 3744888. DOI: 10.1001/2012.jama.11164. View

13.

Ladson G, Dodson W, Sweet S, Archibong A, Kunselman A, Demers L . The effects of metformin with lifestyle therapy in polycystic ovary syndrome: a randomized double-blind study. Fertil Steril. 2011; 95(3):1059-66.e1-7. PMC: 3073705. DOI: 10.1016/j.fertnstert.2010.12.002. View

14.

Brunault P, Jacobi D, Leger J, Bourbao-Tournois C, Huten N, Camus V . Observations regarding 'quality of life' and 'comfort with food' after bariatric surgery: comparison between laparoscopic adjustable gastric banding and sleeve gastrectomy. Obes Surg. 2011; 21(8):1225-31. DOI: 10.1007/s11695-011-0411-4. View

15.

Malone M, Alger-Mayer S, Anderson D . The lifestyle challenge program: a multidisciplinary approach to weight management. Ann Pharmacother. 2005; 39(12):2015-20. DOI: 10.1345/aph.1G287. View

16.

Karlsson J, Taft C, Ryden A, Sjostrom L, Sullivan M . Ten-year trends in health-related quality of life after surgical and conventional treatment for severe obesity: the SOS intervention study. Int J Obes (Lond). 2007; 31(8):1248-61. DOI: 10.1038/sj.ijo.0803573. View

17.

Aftab H, Risstad H, Sovik T, Bernklev T, Hewitt S, Kristinsson J . Five-year outcome after gastric bypass for morbid obesity in a Norwegian cohort. Surg Obes Relat Dis. 2013; 10(1):71-8. DOI: 10.1016/j.soard.2013.05.003. View

18.

Villareal D, Banks M, Sinacore D, Siener C, Klein S . Effect of weight loss and exercise on frailty in obese older adults. Arch Intern Med. 2006; 166(8):860-6. DOI: 10.1001/archinte.166.8.860. View

19.

Levine M, Ganz P . Beyond the development of quality-of-life instruments: where do we go from here?. J Clin Oncol. 2002; 20(9):2215-6. DOI: 10.1200/JCO.2002.20.9.2215. View

20.

Bays H, Pi-Sunyer X, Hemmingsson J, Claudius B, Jensen C, Van Gaal L . Liraglutide 3.0 mg for weight management: weight-loss dependent and independent effects. Curr Med Res Opin. 2016; 33(2):225-229. DOI: 10.1080/03007995.2016.1251892. View