Hypogonadotropic Hypogonadism in Men with Hereditary Hemochromatosis

Overview

Journal Basic Clin Androl

Publisher Biomed Central

Date 2017 Jul 12

PMID 28694969

Citations 9

Authors

Rabih El Osta

Nicolas Grandpre

Nicolas Monnin

Jacques Hubert

Isabelle Koscinski

Affiliations

Soon will be listed here.

Abstract

Hereditary hemochromatosis is a genetic disease that progresses silently. This disease is often diagnosed late when complications appear. Hypogonadotropic hypogonadism (HH) is one of the classical complications of hemochromatosis. Its frequency is declining probably because of earlier diagnosis and better informed physicians. Certain symptoms linked to HH can have an impact on a patient's sexuality, such as decreased libido, erectile dysfunction, and impairment of ejaculation, as well as on his reproductive capacities. This review is based on an online search in English, French and German language publications found in PubMed/Medline, up to 23 September 2016 using the following key word: Male infertility, Hypogonadotropic Hypogonadism, Hereditary Hemochromatosis. Thirty-four papers met these inclusion criteria. This review describes the impact of iron overload on male fertility, resulting in hypogonadotropic hypogonadism and proposes treatment modalities.

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