» Articles » PMID: 28694920

Role of Microglia in Methamphetamine-induced Neurotoxicity

Overview
Date 2017 Jul 12
PMID 28694920
Citations 27
Authors
Affiliations
Soon will be listed here.
Abstract

Methamphetamine (Meth) is an addictive psychostimulant widely abused around the world. The chronic use of Meth produces neurotoxicity featured by dopaminergic terminal damage and microgliosis, resulting in serious neurological and behavioral consequences. Ample evidence indicate that Meth causes microglial activation and resultant secretion of pro-inflammatory molecules leading to neural injury. However, the mechanisms underlying Meth-induced microglial activation remain to be determined. In this review, we attempt to address the effects of Meth on human immunodeficiency virus (HIV)-associated microglia activation both and . Meth abuse not only increases HIV transmission but also exacerbates progression of HIV-associated neurocognitive disorders (HAND) through activation of microglia. In addition, the therapeutic potential of anti-inflammatory drugs on ameliorating Meth-induced microglia activation and resultant neuronal injury is discussed.

Citing Articles

Therapeutic targeting of neuroinflammation in methamphetamine use disorder.

Jeffery N, Mock P, Yang K, Tham C, Israf D, Li H Future Med Chem. 2024; 17(2):237-257.

PMID: 39727147 PMC: 11749361. DOI: 10.1080/17568919.2024.2447226.


Methamphetamine-Induced Blood Pressure Sensitization Correlates with Morphological Alterations within A1/C1 Catecholamine Neurons.

Busceti C, Bucci D, Damato A, De Lucia M, Venturini E, Ferrucci M Int J Mol Sci. 2024; 25(19).

PMID: 39408612 PMC: 11476956. DOI: 10.3390/ijms251910282.


Neonatal brain inflammation enhances methamphetamine-induced reinstated behavioral sensitization in adult rats analyzed with explainable machine learning.

Wang K, Ojeda N, Wang H, Chiang H, Tucci M, Lee J Neurochem Int. 2024; 176:105743.

PMID: 38641026 PMC: 11102812. DOI: 10.1016/j.neuint.2024.105743.


Methamphetamine Enhancement of HIV-1 gp120-Mediated NLRP3 Inflammasome Activation and Resultant Proinflammatory Responses in Rat Microglial Cultures.

Dutta D, Liu J, Xu E, Xiong H Int J Mol Sci. 2024; 25(7).

PMID: 38612400 PMC: 11012125. DOI: 10.3390/ijms25073588.


Methamphetamine enhancement of HIV-1 gp120-mediated NLRP3 inflammasome activation and resultant proinflammatory responses in rat microglial cultures.

Dutta D, Liu J, Xu E, Xiong H Res Sq. 2024; .

PMID: 38168345 PMC: 10760309. DOI: 10.21203/rs.3.rs-3707515/v1.


References
1.
Miyazaki I, Asanuma M, Diaz-Corrales F, Fukuda M, Kitaichi K, Miyoshi K . Methamphetamine-induced dopaminergic neurotoxicity is regulated by quinone-formation-related molecules. FASEB J. 2006; 20(3):571-3. DOI: 10.1096/fj.05-4996fje. View

2.
Mata M, Napier T, Graves S, Mahmood F, Raeisi S, Baum L . Methamphetamine decreases CD4 T cell frequency and alters pro-inflammatory cytokine production in a model of drug abuse. Eur J Pharmacol. 2015; 752:26-33. PMC: 4396630. DOI: 10.1016/j.ejphar.2015.02.002. View

3.
Mizoguchi H, Takuma K, Fukakusa A, Ito Y, Nakatani A, Ibi D . Improvement by minocycline of methamphetamine-induced impairment of recognition memory in mice. Psychopharmacology (Berl). 2007; 196(2):233-41. DOI: 10.1007/s00213-007-0955-0. View

4.
Sekine Y, Ouchi Y, Sugihara G, Takei N, Yoshikawa E, Nakamura K . Methamphetamine causes microglial activation in the brains of human abusers. J Neurosci. 2008; 28(22):5756-61. PMC: 2491906. DOI: 10.1523/JNEUROSCI.1179-08.2008. View

5.
Czub S, Koutsilieri E, Sopper S, Czub M, Stahl-Hennig C, Muller J . Enhancement of central nervous system pathology in early simian immunodeficiency virus infection by dopaminergic drugs. Acta Neuropathol. 2001; 101(2):85-91. DOI: 10.1007/s004010000313. View