Role of Microglia in Methamphetamine-induced Neurotoxicity

Overview

Journal Int J Physiol Pathophysiol Pharmacol

Date 2017 Jul 12

PMID 28694920

Citations 27

Authors

Enquan Xu

Jianuo Liu

Han Liu

Xiaobei Wang

Huangui Xiong

Affiliations

Soon will be listed here.

Abstract

Methamphetamine (Meth) is an addictive psychostimulant widely abused around the world. The chronic use of Meth produces neurotoxicity featured by dopaminergic terminal damage and microgliosis, resulting in serious neurological and behavioral consequences. Ample evidence indicate that Meth causes microglial activation and resultant secretion of pro-inflammatory molecules leading to neural injury. However, the mechanisms underlying Meth-induced microglial activation remain to be determined. In this review, we attempt to address the effects of Meth on human immunodeficiency virus (HIV)-associated microglia activation both and . Meth abuse not only increases HIV transmission but also exacerbates progression of HIV-associated neurocognitive disorders (HAND) through activation of microglia. In addition, the therapeutic potential of anti-inflammatory drugs on ameliorating Meth-induced microglia activation and resultant neuronal injury is discussed.

Citing Articles

Therapeutic targeting of neuroinflammation in methamphetamine use disorder.

Jeffery N, Mock P, Yang K, Tham C, Israf D, Li H Future Med Chem. 2024; 17(2):237-257.

PMID: 39727147 PMC: 11749361. DOI: 10.1080/17568919.2024.2447226.

Methamphetamine-Induced Blood Pressure Sensitization Correlates with Morphological Alterations within A1/C1 Catecholamine Neurons.

Busceti C, Bucci D, Damato A, De Lucia M, Venturini E, Ferrucci M Int J Mol Sci. 2024; 25(19).

PMID: 39408612 PMC: 11476956. DOI: 10.3390/ijms251910282.

Neonatal brain inflammation enhances methamphetamine-induced reinstated behavioral sensitization in adult rats analyzed with explainable machine learning.

Wang K, Ojeda N, Wang H, Chiang H, Tucci M, Lee J Neurochem Int. 2024; 176:105743.

PMID: 38641026 PMC: 11102812. DOI: 10.1016/j.neuint.2024.105743.

Methamphetamine Enhancement of HIV-1 gp120-Mediated NLRP3 Inflammasome Activation and Resultant Proinflammatory Responses in Rat Microglial Cultures.

Dutta D, Liu J, Xu E, Xiong H Int J Mol Sci. 2024; 25(7).

PMID: 38612400 PMC: 11012125. DOI: 10.3390/ijms25073588.

Methamphetamine enhancement of HIV-1 gp120-mediated NLRP3 inflammasome activation and resultant proinflammatory responses in rat microglial cultures.

Dutta D, Liu J, Xu E, Xiong H Res Sq. 2024; .

PMID: 38168345 PMC: 10760309. DOI: 10.21203/rs.3.rs-3707515/v1.

References

Miyazaki I, Asanuma M, Diaz-Corrales F, Fukuda M, Kitaichi K, Miyoshi K . Methamphetamine-induced dopaminergic neurotoxicity is regulated by quinone-formation-related molecules. FASEB J. 2006; 20(3):571-3. DOI: 10.1096/fj.05-4996fje. View

Mata M, Napier T, Graves S, Mahmood F, Raeisi S, Baum L . Methamphetamine decreases CD4 T cell frequency and alters pro-inflammatory cytokine production in a model of drug abuse. Eur J Pharmacol. 2015; 752:26-33. PMC: 4396630. DOI: 10.1016/j.ejphar.2015.02.002. View

Mizoguchi H, Takuma K, Fukakusa A, Ito Y, Nakatani A, Ibi D . Improvement by minocycline of methamphetamine-induced impairment of recognition memory in mice. Psychopharmacology (Berl). 2007; 196(2):233-41. DOI: 10.1007/s00213-007-0955-0. View

Sekine Y, Ouchi Y, Sugihara G, Takei N, Yoshikawa E, Nakamura K . Methamphetamine causes microglial activation in the brains of human abusers. J Neurosci. 2008; 28(22):5756-61. PMC: 2491906. DOI: 10.1523/JNEUROSCI.1179-08.2008. View

Czub S, Koutsilieri E, Sopper S, Czub M, Stahl-Hennig C, Muller J . Enhancement of central nervous system pathology in early simian immunodeficiency virus infection by dopaminergic drugs. Acta Neuropathol. 2001; 101(2):85-91. DOI: 10.1007/s004010000313. View

Roberts A, Maung R, Sejbuk N, Ake C, Kaul M . Alteration of Methamphetamine-induced stereotypic behaviour in transgenic mice expressing HIV-1 envelope protein gp120. J Neurosci Methods. 2009; 186(2):222-5. PMC: 3432271. DOI: 10.1016/j.jneumeth.2009.11.007. View

Maurice T, Su T . The pharmacology of sigma-1 receptors. Pharmacol Ther. 2009; 124(2):195-206. PMC: 2785038. DOI: 10.1016/j.pharmthera.2009.07.001. View

Lull M, Block M . Microglial activation and chronic neurodegeneration. Neurotherapeutics. 2010; 7(4):354-65. PMC: 2951017. DOI: 10.1016/j.nurt.2010.05.014. View

Robson M, Turner R, Naser Z, McCurdy C, OCallaghan J, Huber J . SN79, a sigma receptor antagonist, attenuates methamphetamine-induced astrogliosis through a blockade of OSMR/gp130 signaling and STAT3 phosphorylation. Exp Neurol. 2014; 254:180-9. PMC: 4241368. DOI: 10.1016/j.expneurol.2014.01.020. View

10.

Kettenmann H, Hanisch U, Noda M, Verkhratsky A . Physiology of microglia. Physiol Rev. 2011; 91(2):461-553. DOI: 10.1152/physrev.00011.2010. View

11.

In S, Son E, Rhee D, Pyo S . Modulation of murine macrophage function by methamphetamine. J Toxicol Environ Health A. 2004; 67(23-24):1923-37. DOI: 10.1080/15287390490514589. View

12.

Narendran R, Lopresti B, Mason N, Deuitch L, Paris J, Himes M . Cocaine abuse in humans is not associated with increased microglial activation: an 18-kDa translocator protein positron emission tomography imaging study with [11C]PBR28. J Neurosci. 2014; 34(30):9945-50. PMC: 4107410. DOI: 10.1523/JNEUROSCI.0928-14.2014. View

13.

Cruickshank C, Dyer K . A review of the clinical pharmacology of methamphetamine. Addiction. 2009; 104(7):1085-99. DOI: 10.1111/j.1360-0443.2009.02564.x. View

14.

Zhang S, Wang X, Tian L, Pan J, Lu G, Zhang Y . CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson's disease. J Neuroinflammation. 2011; 8:154. PMC: 3226566. DOI: 10.1186/1742-2094-8-154. View

15.

Beardsley P, Shelton K, Hendrick E, Johnson K . The glial cell modulator and phosphodiesterase inhibitor, AV411 (ibudilast), attenuates prime- and stress-induced methamphetamine relapse. Eur J Pharmacol. 2010; 637(1-3):102-8. PMC: 2878837. DOI: 10.1016/j.ejphar.2010.04.010. View

16.

Stefanski R, Justinova Z, Hayashi T, Takebayashi M, Goldberg S, Su T . Sigma1 receptor upregulation after chronic methamphetamine self-administration in rats: a study with yoked controls. Psychopharmacology (Berl). 2004; 175(1):68-75. DOI: 10.1007/s00213-004-1779-9. View

17.

Brown J, Hanson G, Fleckenstein A . Methamphetamine rapidly decreases vesicular dopamine uptake. J Neurochem. 2000; 74(5):2221-3. DOI: 10.1046/j.1471-4159.2000.0742221.x. View

18.

Gonzalez-Scarano F, Martin-Garcia J . The neuropathogenesis of AIDS. Nat Rev Immunol. 2005; 5(1):69-81. DOI: 10.1038/nri1527. View

19.

Simon S, Domier C, Sim T, Richardson K, Rawson R, Ling W . Cognitive performance of current methamphetamine and cocaine abusers. J Addict Dis. 2002; 21(1):61-74. DOI: 10.1300/j069v21n01_06. View

20.

Park M, Kim H, Lim B, Wylegala A, Toborek M . Methamphetamine-induced occludin endocytosis is mediated by the Arp2/3 complex-regulated actin rearrangement. J Biol Chem. 2013; 288(46):33324-34. PMC: 3829179. DOI: 10.1074/jbc.M113.483487. View