A Comparison of the Effects of Quinolinate and N-methyl-aspartate on Neurons in Rat Piriform Cortex

Overview

Journal Neurosci Lett

Specialty Neurology

Date 1986 Jan 2

PMID 2869453

Citations 5

Authors

J M ffrench-Mullen

N Hori

D O Carpenter

Affiliations

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Abstract

Quinolinate has been proposed to be the endogenous ligand of the N-methyl-aspartate (NMA) receptor in the mammalian central nervous system. We have compared the relative potency and pharmacologic sensitivity of quinolinate- and NMA-induced excitation on pyramidal cells in the rat piriform cortex. Quinolinate was considerably less potent than NMA, but the NMA responses were more sensitive to antagonism by NMA-receptor antagonists. These results suggest that, at least in this preparation, quinolinate and NMA are pharmacologically distinguishable and may act at different receptor sites.

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