Fat-Soluble Vitamin Deficiency in Pediatric Patients with Biliary Atresia

Overview

Journal Gastroenterol Res Pract

Publisher Wiley

Specialty Gastroenterology

Date 2017 Jul 11

PMID 28690638

Citations 6

Authors

Rui Dong

Song Sun

Xiao-Zhou Liu

Zhen Shen

Gong Chen

Shan Zheng

Affiliations

Soon will be listed here.

Abstract

Objective: To analyze the levels of fat-soluble vitamins (FSVs) in pediatric patients with biliary atresia (BA) before and after the Kasai procedure.

Methods: Pediatric patients with obstructive jaundice were enrolled in this study. The FSV levels and liver function before, 2 weeks after, and 1, 3, and 6 months after the Kasai procedure were measured.

Results: FSV deficiency was more obvious in patients with BA than in patients with other cholestatic liver diseases, especially vitamin D deficiency. 25-Hydroxy vitamin D (25-(OH)D) deficiency was more pronounced in younger patients before surgery. The 25-(OH)D level was significantly higher in patients with than without resolution of jaundice 3 months after surgery. At 6 months after surgery, the 25-(OH)D level was abnormally high at 8.76 ng/ml in patients with unresolved jaundice.

Conclusions: Preoperative FSV deficiency, particularly vitamin D deficiency, is common in patients with BA. 25-(OH)D deficiency is more pronounced in younger children before surgery. Postoperative FSV deficiency was still prevalent as shown by the lower 25-(OH)D levels in patients with BA and unresolved jaundice. This required long-term vitamin AD supplementation for pediatric patients with BA and unresolved jaundice after surgery.

Citing Articles

Fat-Soluble Vitamins Deficiency in Pediatric Cholestasis: A Scoping Review.

Degrassi I, Leonardi I, Di Profio E, Montanari C, Zuccotti G, Verduci E Nutrients. 2023; 15(11).

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The Role of Vitamin D and Vitamin D Binding Protein in Chronic Liver Diseases.

Pop T, Sirbe C, Benta G, Mititelu A, Grama A Int J Mol Sci. 2022; 23(18).

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Biomarkers for the diagnosis and post-Kasai portoenterostomy prognosis of biliary atresia: a systematic review and meta-analysis.

He L, Ip D, Tam G, Lui V, Tam P, Chung P Sci Rep. 2021; 11(1):11692.

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Jose Guillot A, Cordeiro A, Donnelly R, Carmen Montesinos M, Garrigues T, Melero A Pharmaceutics. 2020; 12(6).

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Associations between Vitamin D and Liver Function and Liver Fibrosis in Patients with Biliary Atresia.

Zhuang P, Sun S, Dong R, Chen G, Huang Y, Zheng S Gastroenterol Res Pract. 2019; 2019:4621372.

PMID: 31781188 PMC: 6875370. DOI: 10.1155/2019/4621372.

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