Distinct Ventral Pallidal Neural Populations Mediate Separate Symptoms of Depression

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2017 Jul 11

PMID 28689640

Citations 124

Authors

Daniel Knowland

Varoth Lilascharoen

Christopher Pham Pacia

Sora Shin

Eric Hou-Jen Wang

Byung Kook Lim

Affiliations

Soon will be listed here.

Abstract

Major depressive disorder (MDD) patients display a common but often variable set of symptoms making successful, sustained treatment difficult to achieve. Separate depressive symptoms may be encoded by differential changes in distinct circuits in the brain, yet how discrete circuits underlie behavioral subsets of depression and how they adapt in response to stress has not been addressed. We identify two discrete circuits of parvalbumin-positive (PV) neurons in the ventral pallidum (VP) projecting to either the lateral habenula or ventral tegmental area contributing to depression. We find that these populations undergo different electrophysiological adaptations in response to social defeat stress, which are normalized by antidepressant treatment. Furthermore, manipulation of each population mediates either social withdrawal or behavioral despair, but not both. We propose that distinct components of the VP PV circuit can subserve related, yet separate depressive-like phenotypes in mice, which could ultimately provide a platform for symptom-specific treatments of depression.

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