Differences in Neural Correlates of Speech Perception in 3 Month Olds at High and Low Risk for Autism Spectrum Disorder

Overview

Journal J Autism Dev Disord

Publisher Springer

Date 2017 Jul 9

PMID 28688078

Citations 16

Authors

Laura A Edwards

Jennifer B Wagner

Helen Tager-Flusberg

Charles A Nelson

Affiliations

Soon will be listed here.

Abstract

In this study, we investigated neural precursors of language acquisition as potential endophenotypes of autism spectrum disorder (ASD) in 3-month-old infants at high and low familial ASD risk. Infants were imaged using functional near-infrared spectroscopy while they listened to auditory stimuli containing syllable repetitions; their neural responses were analyzed over left and right temporal regions. While female low risk infants showed initial neural activation that decreased over exposure to repetition-based stimuli, potentially indicating a habituation response to repetition in speech, female high risk infants showed no changes in neural activity over exposure. This finding may indicate a potential neural endophenotype of language development or ASD specific to females at risk for the disorder.

Citing Articles

Heterogeneity and convergence across seven neuroimaging modalities: a review of the autism spectrum disorder literature.

Halliday A, Vucic S, Georges B, LaRoche M, Mendoza Pardo M, Swiggard L Front Psychiatry. 2024; 15:1474003.

PMID: 39479591 PMC: 11521827. DOI: 10.3389/fpsyt.2024.1474003.

Neural correlates and predictors of speech and language development in infants at elevated likelihood for autism: a systematic review.

Morrel J, Singapuri K, Landa R, Reetzke R Front Hum Neurosci. 2023; 17:1211676.

PMID: 37662636 PMC: 10469683. DOI: 10.3389/fnhum.2023.1211676.

A Potential Biomarker of Brain Activity in Autism Spectrum Disorders: A Pilot fNIRS Study in Female Preschoolers.

Scaffei E, Mazziotti R, Conti E, Costanzo V, Calderoni S, Stoccoro A Brain Sci. 2023; 13(6).

PMID: 37371429 PMC: 10296408. DOI: 10.3390/brainsci13060951.

Sensory Gating in Neurodevelopmental Disorders: A Scoping Review.

Schulz S, Luszawski M, Hannah K, Stevenson R Res Child Adolesc Psychopathol. 2023; 51(7):1005-1019.

PMID: 37014483 DOI: 10.1007/s10802-023-01058-9.

Functional near-infrared spectroscopy in pediatric clinical research: Different pathophysiologies and promising clinical applications.

Gallagher A, Wallois F, Obrig H Neurophotonics. 2023; 10(2):023517.

PMID: 36873247 PMC: 9982436. DOI: 10.1117/1.NPh.10.2.023517.

References

Fantz R . VISUAL EXPERIENCE IN INFANTS: DECREASED ATTENTION TO FAMILIAR PATTERNS RELATIVE TO NOVEL ONES. Science. 1964; 146(3644):668-70. DOI: 10.1126/science.146.3644.668. View

Key A, Stone W . Same but different: 9-month-old infants at average and high risk for autism look at the same facial features but process them using different brain mechanisms. Autism Res. 2012; 5(4):253-66. PMC: 3422441. DOI: 10.1002/aur.1231. View

Righi G, Tierney A, Tager-Flusberg H, Nelson C . Functional connectivity in the first year of life in infants at risk for autism spectrum disorder: an EEG study. PLoS One. 2014; 9(8):e105176. PMC: 4139321. DOI: 10.1371/journal.pone.0105176. View

Wagner J, Fox S, Tager-Flusberg H, Nelson C . Neural processing of repetition and non-repetition grammars in 7- and 9-month-old infants. Front Psychol. 2011; 2:168. PMC: 3144465. DOI: 10.3389/fpsyg.2011.00168. View

Tong Y, Frederick B . Time lag dependent multimodal processing of concurrent fMRI and near-infrared spectroscopy (NIRS) data suggests a global circulatory origin for low-frequency oscillation signals in human brain. Neuroimage. 2010; 53(2):553-64. PMC: 3133965. DOI: 10.1016/j.neuroimage.2010.06.049. View

Eyler L, Pierce K, Courchesne E . A failure of left temporal cortex to specialize for language is an early emerging and fundamental property of autism. Brain. 2012; 135(Pt 3):949-60. PMC: 3286331. DOI: 10.1093/brain/awr364. View

Wan C, Marchina S, Norton A, Schlaug G . Atypical hemispheric asymmetry in the arcuate fasciculus of completely nonverbal children with autism. Ann N Y Acad Sci. 2012; 1252:332-7. PMC: 4455878. DOI: 10.1111/j.1749-6632.2012.06446.x. View

Boddaert N, Belin P, Chabane N, Poline J, Barthelemy C, Mouren-Simeoni M . Perception of complex sounds: abnormal pattern of cortical activation in autism. Am J Psychiatry. 2003; 160(11):2057-60. DOI: 10.1176/appi.ajp.160.11.2057. View

Lloyd-Fox S, Blasi A, Elwell C, Charman T, Murphy D, Johnson M . Reduced neural sensitivity to social stimuli in infants at risk for autism. Proc Biol Sci. 2013; 280(1758):20123026. PMC: 3619456. DOI: 10.1098/rspb.2012.3026. View

10.

Tierney A, Gabard-Durnam L, Vogel-Farley V, Tager-Flusberg H, Nelson C . Developmental trajectories of resting EEG power: an endophenotype of autism spectrum disorder. PLoS One. 2012; 7(6):e39127. PMC: 3380047. DOI: 10.1371/journal.pone.0039127. View

11.

Wolff J, Gerig G, Lewis J, Soda T, Styner M, Vachet C . Altered corpus callosum morphology associated with autism over the first 2 years of life. Brain. 2015; 138(Pt 7):2046-58. PMC: 4492413. DOI: 10.1093/brain/awv118. View

12.

Perani D, Saccuman M, Scifo P, Anwander A, Awander A, Spada D . Neural language networks at birth. Proc Natl Acad Sci U S A. 2011; 108(38):16056-61. PMC: 3179044. DOI: 10.1073/pnas.1102991108. View

13.

Guiraud J, Kushnerenko E, Tomalski P, Davies K, Ribeiro H, Johnson M . Differential habituation to repeated sounds in infants at high risk for autism. Neuroreport. 2011; 22(16):845-9. DOI: 10.1097/WNR.0b013e32834c0bec. View

14.

Viding E, Blakemore S . Endophenotype approach to developmental psychopathology: implications for autism research. Behav Genet. 2006; 37(1):51-60. DOI: 10.1007/s10519-006-9105-4. View

15.

Sinha P, Kjelgaard M, Gandhi T, Tsourides K, Cardinaux A, Pantazis D . Autism as a disorder of prediction. Proc Natl Acad Sci U S A. 2014; 111(42):15220-5. PMC: 4210351. DOI: 10.1073/pnas.1416797111. View

16.

Fox S, Wagner J, Shrock C, Tager-Flusberg H, Nelson C . Neural processing of facial identity and emotion in infants at high-risk for autism spectrum disorders. Front Hum Neurosci. 2013; 7:89. PMC: 3620489. DOI: 10.3389/fnhum.2013.00089. View

17.

Kameyama M, Fukuda M, Uehara T, Mikuni M . Sex and age dependencies of cerebral blood volume changes during cognitive activation: a multichannel near-infrared spectroscopy study. Neuroimage. 2004; 22(4):1715-21. DOI: 10.1016/j.neuroimage.2004.03.050. View

18.

Keehn B, Wagner J, Tager-Flusberg H, Nelson C . Functional connectivity in the first year of life in infants at-risk for autism: a preliminary near-infrared spectroscopy study. Front Hum Neurosci. 2013; 7:444. PMC: 3734360. DOI: 10.3389/fnhum.2013.00444. View

19.

Sommerville J, Woodward A, Needham A . Action experience alters 3-month-old infants' perception of others' actions. Cognition. 2005; 96(1):B1-11. PMC: 3908452. DOI: 10.1016/j.cognition.2004.07.004. View

20.

Gottesman I, Gould T . The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry. 2003; 160(4):636-45. DOI: 10.1176/appi.ajp.160.4.636. View