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Inner Ear Ossification and Mineralization Kinetics in Human Embryonic Development - Microtomographic and Histomorphological Study

Overview
Journal Sci Rep
Specialty Science
Date 2017 Jul 8
PMID 28684743
Citations 16
Authors
Celine Richard
Guillaume Courbon
Norbert Laroche
Jean Michel Prades
Laurence Vico
Luc Malaval
Affiliations
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Abstract

Little is known about middle and inner ear development during the second and third parts of human fetal life. Using ultra-high resolution Microcomputed Tomography coupled with bone histology, we performed the first quantitative middle and inner ear ossification/mineralization evaluation of fetuses between 17 and 39 weeks of gestational age. We show distinct ossification paces between ossicles, with a belated development of the stapes. A complete cochlear bony covering is observed within the time-frame of the onset of hearing, whereas distinct time courses of ossification for semicircular canal envelopes are observed in relation to the start of vestibular functions. The study evidences a spatio-temporal relationship between middle and inner ear structure development and the onset of hearing and balance, critical senses for the fetal adaptation to birth.

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References
1.
Saliba I, Sidani K . Prognostic indicators for sensorineural hearing loss in temporal bone histiocytosis. Int J Pediatr Otorhinolaryngol. 2009; 73(12):1616-20. DOI: 10.1016/j.ijporl.2009.07.010. View
2.
Moore J, Perazzo L, Braun A . Time course of axonal myelination in the human brainstem auditory pathway. Hear Res. 1995; 87(1-2):21-31. DOI: 10.1016/0378-5955(95)00073-d. View
3.
Rodriguez-Vazquez J, Murakami G, Verdugo-Lopez S, Abe S, Fujimiya M . Closure of the middle ear with special reference to the development of the tegmen tympani of the temporal bone. J Anat. 2011; 218(6):690-8. PMC: 3125903. DOI: 10.1111/j.1469-7580.2011.01378.x. View
4.
Rodriguez-Vazquez J . Development of the stapedius muscle and pyramidal eminence in humans. J Anat. 2009; 215(3):292-9. PMC: 2750762. DOI: 10.1111/j.1469-7580.2009.01105.x. View
5.
Lv K, Huang H, Lu Y, Qin C, Li Z, Feng J . Circling behavior developed in Dmp1 null mice is due to bone defects in the vestibular apparatus. Int J Biol Sci. 2010; 6(6):537-45. PMC: 2945924. DOI: 10.7150/ijbs.6.537. View