Sleep Loss As a Trigger of Mood Episodes in Bipolar Disorder: Individual Differences Based on Diagnostic Subtype and Gender

Overview

Journal Br J Psychiatry

Publisher Cambridge University Press

Specialty Psychiatry

Date 2017 Jul 8

PMID 28684405

Citations 43

Authors

Katie Swaden Lewis

Katherine Gordon-Smith

Liz Forty

Arianna Di Florio

Nick Craddock

Lisa Jones

Ian Jones

Affiliations

Soon will be listed here.

Abstract

Sleep loss may trigger mood episodes in people with bipolar disorder but individual differences could influence vulnerability to this trigger.To determine whether bipolar subtype (bipolar disorder type I (BP-I) or II (BD-II)) and gender were associated with vulnerability to the sleep loss trigger.During a semi-structured interview, 3140 individuals (68% women) with bipolar disorder (66% BD-I) reported whether sleep loss had triggered episodes of high or low mood. DSM-IV diagnosis of bipolar subtype was derived from case notes and interview data.Sleep loss triggering episodes of high mood was associated with female gender (odds ratio (OR) = 1.43, 95% CI 1.17-1.75, < 0.001) and BD-I subtype (OR = 2.81, 95% CI 2.26-3.50, < 0.001). Analyses on sleep loss triggering low mood were not significant following adjustment for confounders.Gender and bipolar subtype may increase vulnerability to high mood following sleep deprivation. This should be considered in situations where patients encounter sleep disruption, such as shift work and international travel.

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