Relationship Between Trajectories of Serum Albumin Levels and Technique Failure According to Diabetic Status in Peritoneal Dialysis Patients: A Joint Modeling Approach

Overview

Journal Kidney Res Clin Pract

Specialty Nephrology

Date 2017 Jul 7

PMID 28680826

Citations 9

Authors

Mehri Khoshhali

Iraj Kazemi

S Mohsen Hosseini

Shiva Seirafian

Affiliations

Soon will be listed here.

Abstract

Background: In peritoneal dialysis, technique failure is an important metric to be considered. This study was performed in order to identify the relationship between trajectories of serum albumin levels and peritoneal dialysis technique failure on end-stage renal disease patients according to diabetic status. Furthermore, this study was performed to reveal predictors of serum albumin and technique failure simultaneously.

Methods: This retrospective cohort study included 300 (189 non-diabetic and 111 diabetic) end-stage renal disease patients on continuous ambulatory peritoneal dialysis treated in Al-Zahra Hospital, Isfahan, Iran, from May 2005 to March 2015. Bayesian joint modeling was carried out in order to determine the relationship between trajectories of serum albumin levels and peritoneal dialysis technique failure in the patients according to diabetic status. Death from all causes was considered as a competing risk.

Results: Using joint modeling approach, a relationship between trajectories of serum albumin with hazard of transfer to hemodialysis was estimated as -0.720 (95% confidence interval [CI], -0.971 to -0.472) for diabetic and -0.784 (95% CI, -0.963 to -0.587) for non-diabetic patients. From our findings it was showed that predictors of low serum albumin over time were time on peritoneal dialysis for diabetic patients and increase in age and time on peritoneal dialysis, history of previous hemodialysis, and lower body mass index in non-diabetic patients.

Conclusion: The results of current study showed that controlling serum albumin over time in non-diabetic and diabetic patients undergoing continuous ambulatory peritoneal dialysis treatment can decrease risk of adverse outcomes during the peritoneal dialysis period.

Citing Articles

Incidence and Risk Factors Associated with Technique Failure in the First Year of Peritoneal Dialysis: A Single Center Retrospective Cohort Study in Southern China.

Dong X, Wu H, Ye H, Yi C, Diao X, Liu R BMC Nephrol. 2022; 23(1):207.

PMID: 35690721 PMC: 9188716. DOI: 10.1186/s12882-022-02833-4.

Serum albumin at 1 year after peritoneal dialysis predicts long-term outcomes on continuous ambulatory peritoneal dialysis.

Jin L, Wang X, Ma Y, Zheng J, Lu W, Xie L Ren Fail. 2022; 44(1):252-257.

PMID: 35166186 PMC: 8856101. DOI: 10.1080/0886022X.2022.2033264.

Effect of Serum Albumin Changes on Mortality in Patients with Peritoneal Dialysis: A Joint Modeling Approach and Personalized Dynamic Risk Predictions.

Basol M, Goksuluk D, Sipahioglu M, Karaagaoglu E Biomed Res Int. 2021; 2021:6612464.

PMID: 34337034 PMC: 8319732. DOI: 10.1155/2021/6612464.

Analysis of risk factors and construction of prediction model of drop out from peritoneal dialysis.

Li L, Pei H, Liu Z, Zhang J Medicine (Baltimore). 2021; 100(3):e24195.

PMID: 33546035 PMC: 7837897. DOI: 10.1097/MD.0000000000024195.

Bayesian joint modelling of longitudinal and time to event data: a methodological review.

Alsefri M, Sudell M, Garcia-Finana M, Kolamunnage-Dona R BMC Med Res Methodol. 2020; 20(1):94.

PMID: 32336264 PMC: 7183597. DOI: 10.1186/s12874-020-00976-2.

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