Health Related Quality of Life Among Schoolchildren Aged 12-13 years in Relation to Food Hypersensitivity Phenotypes: a Population-based Study

Overview

Journal Clin Transl Allergy

Publisher Wiley

Specialty Allergy & Immunology

Date 2017 Jul 7

PMID 28680560

Citations 9

Authors

Asa Strinnholm

Linnea Hedman

Anna Winberg

Sven-Arne Jansson

Viveca Lindh

Eva Ronmark

Affiliations

Soon will be listed here.

Abstract

Background: While Health Related Quality of Life has been investigated among children with IgE-mediated food allergy, less is known about quality of life among children with other types of hypersensitivity to food. The aim of this study was to investigate Health Related Quality of Life (HRQL) in children with and without food hypersensitivity. Further, we compared HRQL between children with different phenotypes of food hypersensitivity.

Methods: In a large population-based cohort of schoolchildren in Northern Sweden, the parents of 2612 (96% of invited) completed a questionnaire. All 125 (5%) children who reported complete elimination of milk, egg, fish or wheat due to food hypersensitivity were invited to a clinical examination and 94 children participated. Of these, 75 children also completed a generic (KIDSCREEN-52) and a disease-specific HRQL questionnaire (FAQLQ-TF). Thereafter, these children were categorised into the different phenotypes: current food allergy, outgrown food allergy, and lactose intolerance. Additionally, 209 children with unrestricted diets answered the generic questionnaire.

Results: The median score of all KIDSCREEN-52 domains were above the population norm of 50 both in children with and without food hypersensitivity. No significant differences in distribution in generic or disease-specific HRQL were found between children with or without food hypersensitivity. There were no significant differences in HRQL between children with different phenotypes of food hypersensitivity. However, children with current food allergy tended to have the lowest HRQL. Further, poor HRQL defined as ≥75th percentile for the disease specific score was significantly more common in the current food allergy phenotype in the domain Emotional impact and the total FAQLQ, compared to the other phenotypes.

Conclusions: In this population-based study, 12-13 year old children reported good HRQL regardless of having food hypersensitivity or not. However, the children with the current phenotype reported lower HRQL than the other phenotypes.

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References

Rona R, Keil T, Summers C, Gislason D, Zuidmeer L, Sodergren E . The prevalence of food allergy: a meta-analysis. J Allergy Clin Immunol. 2007; 120(3):638-46. DOI: 10.1016/j.jaci.2007.05.026. View

DunnGalvin A, Koman E, Raver E, Frome H, Adams M, Keena A . An Examination of the Food Allergy Quality of Life Questionnaire Performance in a Countrywide American Sample of Children: Cross-Cultural Differences in Age and Impact in the United States and Europe. J Allergy Clin Immunol Pract. 2016; 5(2):363-368.e2. DOI: 10.1016/j.jaip.2016.09.049. View

Le T, Flokstra-de Blok B, van Hoffen E, Lebens A, Goossens N, Dubois A . Quality of life is more impaired in patients seeking medical care for food allergy. Int Arch Allergy Immunol. 2013; 162(4):335-9. DOI: 10.1159/000354925. View

Antolin-Amerigo D, Manso L, Caminati M, de la Hoz Caballer B, Cerecedo I, Muriel A . Quality of life in patients with food allergy. Clin Mol Allergy. 2016; 14:4. PMC: 4757995. DOI: 10.1186/s12948-016-0041-4. View

Winberg A, Strinnholm A, Hedman L, West C, Perzanowski M, Ronmark E . High incidence and remission of reported food hypersensitivity in Swedish children followed from 8 to 12 years of age - a population based cohort study. Clin Transl Allergy. 2015; 4:32. PMC: 4406030. DOI: 10.1186/2045-7022-4-32. View

Flokstra-de Blok B, DunnGalvin A, Vlieg-Boerstra B, Oude Elberink J, Duiverman E, Hourihane J . Development and validation of a self-administered Food Allergy Quality of Life Questionnaire for children. Clin Exp Allergy. 2008; 39(1):127-37. DOI: 10.1111/j.1365-2222.2008.03120.x. View

Winberg A, West C, Strinnholm A, Nordstrom L, Hedman L, Ronmark E . Milk allergy is a minor cause of milk avoidance due to perceived hypersensitivity among schoolchildren in Northern Sweden. Acta Paediatr. 2015; 105(2):206-14. DOI: 10.1111/apa.13253. View

Usai-Satta P, Scarpa M, Oppia F, Cabras F . Lactose malabsorption and intolerance: What should be the best clinical management?. World J Gastrointest Pharmacol Ther. 2012; 3(3):29-33. PMC: 3437438. DOI: 10.4292/wjgpt.v3.i3.29. View

Ostblom E, Egmar A, Gardulf A, Lilja G, Wickman M . The impact of food hypersensitivity reported in 9-year-old children by their parents on health-related quality of life. Allergy. 2008; 63(2):211-8. DOI: 10.1111/j.1398-9995.2007.01559.x. View

10.

Flokstra-de Blok B, DunnGalvin A, Vlieg-Boerstra B, Oude Elberink J, Duiverman E, Hourihane J . Development and validation of the self-administered Food Allergy Quality of Life Questionnaire for adolescents. J Allergy Clin Immunol. 2008; 122(1):139-44, 144.e1-2. DOI: 10.1016/j.jaci.2008.05.008. View

11.

Bjerg A, Sandstrom T, Lundback B, Ronmark E . Time trends in asthma and wheeze in Swedish children 1996-2006: prevalence and risk factors by sex. Allergy. 2009; 65(1):48-55. DOI: 10.1111/j.1398-9995.2009.02105.x. View

12.

Mikkelsen A, Borres M, Bjorkelund C, Lissner L, Oxelmark L . The food hypersensitivity family impact (FLIP) questionnaire - development and first results. Pediatr Allergy Immunol. 2013; 24(6):574-81. DOI: 10.1111/pai.12105. View

13.

Ronmark E, Bjerg A, Perzanowski M, Platts-Mills T, Lundback B . Major increase in allergic sensitization in schoolchildren from 1996 to 2006 in northern Sweden. J Allergy Clin Immunol. 2009; 124(2):357-63, 63.e1-15. PMC: 2747664. DOI: 10.1016/j.jaci.2009.05.011. View

14.

Berman A, Liu B, Ullman S, Jadback I, Engstrom K . Children's Quality of Life Based on the KIDSCREEN-27: Child Self-Report, Parent Ratings and Child-Parent Agreement in a Swedish Random Population Sample. PLoS One. 2016; 11(3):e0150545. PMC: 4784934. DOI: 10.1371/journal.pone.0150545. View

15.

Salvilla S, Dubois A, Flokstra-de Blok B, Panesar S, Worth A, Patel S . Disease-specific health-related quality of life instruments for IgE-mediated food allergy. Allergy. 2014; 69(7):834-44. DOI: 10.1111/all.12427. View

16.

Jansson S, Heibert-Arnlind M, Middelveld R, Bengtsson U, Sundqvist A, Kallstrom-Bengtsson I . Health-related quality of life, assessed with a disease-specific questionnaire, in Swedish adults suffering from well-diagnosed food allergy to staple foods. Clin Transl Allergy. 2013; 3:21. PMC: 3702411. DOI: 10.1186/2045-7022-3-21. View

17.

Cohen B, Noone S, Munoz-Furlong A, Sicherer S . Development of a questionnaire to measure quality of life in families with a child with food allergy. J Allergy Clin Immunol. 2004; 114(5):1159-63. DOI: 10.1016/j.jaci.2004.08.007. View

18.

Strinnholm A, Brulin C, Lindh V . Experiences of double-blind, placebo-controlled food challenges (DBPCFC): a qualitative analysis of mothers' experiences. J Child Health Care. 2010; 14(2):179-88. DOI: 10.1177/1367493509359227. View

19.

Bollinger M, Dahlquist L, Mudd K, Sonntag C, Dillinger L, McKenna K . The impact of food allergy on the daily activities of children and their families. Ann Allergy Asthma Immunol. 2006; 96(3):415-21. DOI: 10.1016/S1081-1206(10)60908-8. View

20.

Strinnholm A, Winberg A, Hedman L, Ronmark E, Lindh V . Reintroduction failure is common among adolescents after double-blind placebo-controlled food challenges. Acta Paediatr. 2016; 106(2):282-287. DOI: 10.1111/apa.13673. View