The Sweet Tooth of the Circadian Clock

Overview

Journal Biochem Soc Trans

Specialty Biochemistry

Date 2017 Jul 5

PMID 28673939

Citations 5

Authors

Minnie Fu

Xiaoyong Yang

Affiliations

Soon will be listed here.

Abstract

The endogenous circadian clock is a key regulator of daily metabolic processes. On the other hand, circadian clocks in a broad range of tissues can be tuned by extrinsic and intrinsic metabolic cues. The bidirectional interaction between circadian clocks and metabolism involves both transcriptional and post-translational mechanisms. Nuclear receptors exemplify the transcriptional programs that couple molecular clocks to metabolism. The post-translational modifications of the core clock machinery are known to play a key role in metabolic entrainment of circadian clocks. O-linked -acetylglucosamine modification (O-GlcNAcylation) of intracellular proteins is a key mediator of metabolic response to nutrient availability. This review highlights our current understanding of the role of protein O-GlcNAcylation in mediating metabolic input and output of the circadian clock.

Citing Articles

Influence of circadian rhythm on effects induced by mechanical strain in periodontal ligament cells.

Peters L, Marciniak J, Kutschera E, Luiz C, Kuchler E, Kirschneck C J Orofac Orthop. 2024; .

PMID: 39134880 DOI: 10.1007/s00056-024-00542-1.

Circadian Rhythms in Cardiovascular Metabolism.

Lal H, Verma S, Wang Y, Xie M, Young M Circ Res. 2024; 134(6):635-658.

PMID: 38484029 PMC: 10947116. DOI: 10.1161/CIRCRESAHA.123.323520.

Chronodentistry: the role & potential of molecular clocks in oral medicine.

Janjic K, Agis H BMC Oral Health. 2019; 19(1):32.

PMID: 30760278 PMC: 6375164. DOI: 10.1186/s12903-019-0720-x.

O-GlcNAcylation of PERIOD regulates its interaction with CLOCK and timing of circadian transcriptional repression.

Li Y, Liu X, Vanselow J, Zheng H, Schlosser A, Chiu J PLoS Genet. 2019; 15(1):e1007953.

PMID: 30703153 PMC: 6372208. DOI: 10.1371/journal.pgen.1007953.

Nutrient regulation of signaling and transcription.

Hart G J Biol Chem. 2019; 294(7):2211-2231.

PMID: 30626734 PMC: 6378989. DOI: 10.1074/jbc.AW119.003226.

References

Taylor R, Parker G, Hazel M, Soesanto Y, Fuller W, Yazzie M . Glucose deprivation stimulates O-GlcNAc modification of proteins through up-regulation of O-linked N-acetylglucosaminyltransferase. J Biol Chem. 2008; 283(10):6050-7. DOI: 10.1074/jbc.M707328200. View

Chen H, Isayama K, Kumazawa M, Zhao L, Yamauchi N, Shigeyoshi Y . Integration of the nuclear receptor REV-ERBα linked with circadian oscillators in the expressions of Alas1, Ppargc1a, and Il6 genes in rat granulosa cells. Chronobiol Int. 2015; 32(6):739-49. DOI: 10.3109/07420528.2015.1042582. View

Yang X . A wheel of time: the circadian clock, nuclear receptors, and physiology. Genes Dev. 2010; 24(8):741-7. PMC: 2854389. DOI: 10.1101/gad.1920710. View

Liu F, Iqbal K, Grundke-Iqbal I, Hart G, Gong C . O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease. Proc Natl Acad Sci U S A. 2004; 101(29):10804-9. PMC: 490015. DOI: 10.1073/pnas.0400348101. View

Ruan H, Singh J, Li M, Wu J, Yang X . Cracking the O-GlcNAc code in metabolism. Trends Endocrinol Metab. 2013; 24(6):301-9. PMC: 3783028. DOI: 10.1016/j.tem.2013.02.002. View

Chen L, Yang G . PPARs Integrate the Mammalian Clock and Energy Metabolism. PPAR Res. 2014; 2014:653017. PMC: 3945976. DOI: 10.1155/2014/653017. View

Huang G, Zhang F, Ye Q, Wang H . The circadian clock regulates autophagy directly through the nuclear hormone receptor Nr1d1/Rev-erbα and indirectly via Cebpb/(C/ebpβ) in zebrafish. Autophagy. 2016; 12(8):1292-309. PMC: 4968235. DOI: 10.1080/15548627.2016.1183843. View

Son G, Chung S, Kim K . The adrenal peripheral clock: glucocorticoid and the circadian timing system. Front Neuroendocrinol. 2011; 32(4):451-65. DOI: 10.1016/j.yfrne.2011.07.003. View

Asher G, Gatfield D, Stratmann M, Reinke H, Dibner C, Kreppel F . SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell. 2008; 134(2):317-28. DOI: 10.1016/j.cell.2008.06.050. View

10.

Weitzman E . Circadian rhythms and episodic hormone secretion in man. Annu Rev Med. 1976; 27:225-43. DOI: 10.1146/annurev.me.27.020176.001301. View

11.

Preitner N, Damiola F, Lopez-Molina L, Zakany J, Duboule D, Albrecht U . The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell. 2002; 110(2):251-60. DOI: 10.1016/s0092-8674(02)00825-5. View

12.

Ko C, Takahashi J . Molecular components of the mammalian circadian clock. Hum Mol Genet. 2006; 15 Spec No 2:R271-7. DOI: 10.1093/hmg/ddl207. View

13.

Cai W, Rambaud J, Teboul M, Masse I, Benoit G, Gustafsson J . Expression levels of estrogen receptor beta are modulated by components of the molecular clock. Mol Cell Biol. 2007; 28(2):784-93. PMC: 2223432. DOI: 10.1128/MCB.00233-07. View

14.

Wang N, Yang G, Jia Z, Zhang H, Aoyagi T, Soodvilai S . Vascular PPARgamma controls circadian variation in blood pressure and heart rate through Bmal1. Cell Metab. 2008; 8(6):482-91. PMC: 5484540. DOI: 10.1016/j.cmet.2008.10.009. View

15.

Nakahata Y, Kaluzova M, Grimaldi B, Sahar S, Hirayama J, Chen D . The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell. 2008; 134(2):329-40. PMC: 3526943. DOI: 10.1016/j.cell.2008.07.002. View

16.

Kanno Y, Otsuka S, Hiromasa T, Nakahama T, Inouye Y . Diurnal difference in CAR mRNA expression. Nucl Recept. 2004; 2(1):6. PMC: 517509. DOI: 10.1186/1478-1336-2-6. View

17.

Le Minh N, Damiola F, Tronche F, Schutz G, Schibler U . Glucocorticoid hormones inhibit food-induced phase-shifting of peripheral circadian oscillators. EMBO J. 2001; 20(24):7128-36. PMC: 125339. DOI: 10.1093/emboj/20.24.7128. View

18.

Markson J, Piechura J, Puszynska A, OShea E . Circadian control of global gene expression by the cyanobacterial master regulator RpaA. Cell. 2013; 155(6):1396-408. PMC: 3935230. DOI: 10.1016/j.cell.2013.11.005. View

19.

Olszewski N, West C, Sassi S, Hartweck L . O-GlcNAc protein modification in plants: Evolution and function. Biochim Biophys Acta. 2009; 1800(2):49-56. PMC: 2815191. DOI: 10.1016/j.bbagen.2009.11.016. View

20.

Nakamura T, Moriya T, Inoue S, Shimazoe T, Watanabe S, Ebihara S . Estrogen differentially regulates expression of Per1 and Per2 genes between central and peripheral clocks and between reproductive and nonreproductive tissues in female rats. J Neurosci Res. 2005; 82(5):622-30. DOI: 10.1002/jnr.20677. View