Iron Concentration in Deep Gray Matter Structures is Associated with Worse Visual Memory Performance in Healthy Young Adults
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Neurology
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Abnormally high deposition of iron can contribute to neurodegenerative disorders with cognitive impairment. Since previous studies investigating cognition-brain iron accumulation relationships focused on elderly people, our aim was to explore the association between iron concentration in subcortical nuclei and two types of memory performances in a healthy young population. Gender difference was found only in the globus pallidus. Our results showed that iron load characterized by R2* value on the MRI in the caudate and putamen was related to visual memory, while verbal memory was unrelated to iron concentration.
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Raab P, Ropele S, Bultmann E, Salcher R, Lanfermann H, Wattjes M Neuroradiology. 2021; 64(5):1021-1031.
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Persson J, Garzon B, Sitnikov R, Backman L, Kalpouzos G Brain Struct Funct. 2020; 225(2):735-749.
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