Signaling Molecules Governing Pluripotency and Early Lineage Commitments in Human Pluripotent Stem Cells

Overview

Journal Cell J

Specialty Cell Biology

Date 2017 Jul 4

PMID 28670512

Citations 5

Authors

Ali Fathi

Shahram Eisa-Beygi

Hossein Baharvand

Affiliations

Soon will be listed here.

Abstract

Signaling in pluripotent stem cells is a complex and dynamic process involving multiple mediators, finely tuned to balancing pluripotency and differentiation states. Characterizing and modifying the necessary signaling pathways to attain desired cell types is required for stem-cell applications in various fields of regenerative medicine. These signals may help enhance the differentiation potential of pluripotent cells towards each of the embryonic lineages and enable us to achieve pure cultures of various cell types. This review provides a timely synthesis of recent advances into how maintenance of pluripotency in hPSCs is regulated by extrinsic cues, such as the fibroblast growth factor (FGF) and ACTIVIN signaling pathways, their interplay with other signaling pathways, namely, wingless- type MMTV integration site family (WNT) and mammalian target of rapamycin (mTOR), and the pathways governing the determination of multiple lineages.

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