Non-alcoholic Fatty Liver Disease, to Struggle with the Strangle: Oxygen Availability in Fatty Livers

Overview

Journal Redox Biol

Specialties Biology
Cell Biology
Endocrinology

Date 2017 Jul 2

PMID 28667907

Citations 17

Authors

Sarit Anavi

Zecharia Madar

Oren Tirosh

Affiliations

Soon will be listed here.

Abstract

Nonalcoholic fatty liver diseases (NAFLD) is one of the most common chronic liver disease in Western countries. Oxygen is a central component of the cellular microenvironment, which participate in the regulation of cell survival, differentiation, functions and energy metabolism. Accordingly, sufficient oxygen supply is an important factor for tissue durability, mainly in highly metabolic tissues, such as the liver. Accumulating evidence from the past few decades provides strong support for the existence of interruptions in oxygen availability in fatty livers. This outcome may be the consequence of both, impaired systemic microcirculation and cellular membrane modifications which occur under steatotic conditions. This review summarizes current knowledge regarding the main factors which can affect oxygen supply in fatty liver.

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References

Rosenstengel S, Stoeppeler S, Bahde R, Spiegel H, Palmes D . Type of steatosis influences microcirculation and fibrogenesis in different rat strains. J Invest Surg. 2011; 24(6):273-82. DOI: 10.3109/08941939.2011.586094. View

Brunt E, Janney C, Di Bisceglie A, Neuschwander-Tetri B, Bacon B . Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol. 1999; 94(9):2467-74. DOI: 10.1111/j.1572-0241.1999.01377.x. View

Targher G, Day C, Bonora E . Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N Engl J Med. 2010; 363(14):1341-50. DOI: 10.1056/NEJMra0912063. View

McPherson D . Circulatory dysfunction in NAFLD--which is first, which is last, and what do we do in between?. Hepatology. 2005; 42(2):270-2. DOI: 10.1002/hep.20834. View

Bogaerts E, Heindryckx F, Devisscher L, Paridaens A, Vandewynckel Y, Van den Bussche A . Time-dependent effect of hypoxia on tumor progression and liver progenitor cell markers in primary liver tumors. PLoS One. 2015; 10(3):e0119555. PMC: 4368520. DOI: 10.1371/journal.pone.0119555. View

Huang-Doran I, Zhang C, Vidal-Puig A . Extracellular Vesicles: Novel Mediators of Cell Communication In Metabolic Disease. Trends Endocrinol Metab. 2016; 28(1):3-18. DOI: 10.1016/j.tem.2016.10.003. View

Iwakiri Y, Groszmann R . Vascular endothelial dysfunction in cirrhosis. J Hepatol. 2007; 46(5):927-34. DOI: 10.1016/j.jhep.2007.02.006. View

Park J, Tan H, Datta A, Lai R, Zhang H, Meng W . Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes. Mol Cell Proteomics. 2010; 9(6):1085-99. PMC: 2877972. DOI: 10.1074/mcp.M900381-MCP200. View

Nizet V, Johnson R . Interdependence of hypoxic and innate immune responses. Nat Rev Immunol. 2009; 9(9):609-17. PMC: 4343208. DOI: 10.1038/nri2607. View

10.

Baffy G . Kupffer cells in non-alcoholic fatty liver disease: the emerging view. J Hepatol. 2009; 51(1):212-23. PMC: 2694233. DOI: 10.1016/j.jhep.2009.03.008. View

11.

Galea A, Brown A . Special relationship between sterols and oxygen: were sterols an adaptation to aerobic life?. Free Radic Biol Med. 2009; 47(6):880-9. DOI: 10.1016/j.freeradbiomed.2009.06.027. View

12.

Erdogmus B, Tamer A, Buyukkaya R, Yazici B, Buyukkaya A, Korkut E . Portal vein hemodynamics in patients with non-alcoholic fatty liver disease. Tohoku J Exp Med. 2008; 215(1):89-93. DOI: 10.1620/tjem.215.89. View

13.

Armstrong M, Adams L, Canbay A, Syn W . Extrahepatic complications of nonalcoholic fatty liver disease. Hepatology. 2013; 59(3):1174-97. DOI: 10.1002/hep.26717. View

14.

McCuskey R, Ito Y, Robertson G, McCuskey M, Perry M, Farrell G . Hepatic microvascular dysfunction during evolution of dietary steatohepatitis in mice. Hepatology. 2004; 40(2):386-93. DOI: 10.1002/hep.20302. View

15.

Serracino-Inglott F, Habib N, Mathie R . Hepatic ischemia-reperfusion injury. Am J Surg. 2001; 181(2):160-6. DOI: 10.1016/s0002-9610(00)00573-0. View

16.

Fabbrini E, Sullivan S, Klein S . Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology. 2009; 51(2):679-89. PMC: 3575093. DOI: 10.1002/hep.23280. View

17.

Ren Y, Hao P, Dutta B, Cheow E, Sim K, Gan C . Hypoxia modulates A431 cellular pathways association to tumor radioresistance and enhanced migration revealed by comprehensive proteomic and functional studies. Mol Cell Proteomics. 2012; 12(2):485-98. PMC: 3567868. DOI: 10.1074/mcp.M112.018325. View

18.

Barnea M, Shamay A, Stark A, Madar Z . A high-fat diet has a tissue-specific effect on adiponectin and related enzyme expression. Obesity (Silver Spring). 2006; 14(12):2145-53. DOI: 10.1038/oby.2006.251. View

19.

Li Z, Agellon L, Allen T, Umeda M, Jewell L, Mason A . The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis. Cell Metab. 2006; 3(5):321-31. DOI: 10.1016/j.cmet.2006.03.007. View

20.

Mainali L, Raguz M, OBrien W, Subczynski W . Properties of membranes derived from the total lipids extracted from the human lens cortex and nucleus. Biochim Biophys Acta. 2013; 1828(6):1432-40. PMC: 3633468. DOI: 10.1016/j.bbamem.2013.02.006. View