Anti-inflammatory Effect of Galectin-1 in a Murine Model of Atopic Dermatitis

Overview

Journal J Mol Med (Berl)

Specialty General Medicine

Date 2017 Jul 1

PMID 28664215

Citations 7

Authors

Mab Pereira Correa

Frans Eberth Costa Andrade

Alexandre Dantas Gimenes

Cristiane Damas Gil

Affiliations

Soon will be listed here.

Abstract

Key Messages: Pharmacological treatment with rGal-1 reduces clinical signs of atopic dermatitis. Systemic treatment with rGal-1 inhibits eosinophil and mast cell influx in the skin of AD animals. rGal-1 reduced local eotaxin levels and systemic IL-17 levels. The inhibition of disease progression induced by rGal-1 was correlated with upregulation of phosphorylated ERK.

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