Combination of Bortezomib-based Chemotherapy and Extracorporeal Free Light Chain Removal for Treating Cast Nephropathy in Multiple Myeloma

Overview

Journal NDT Plus

Publisher Oxford University Press

Specialty Nephrology

Date 2017 Jun 29

PMID 28657037

Citations 3

Authors

Ulrike Bachmann

Ralf Schindler

Markus Storr

Andreas Kahl

Achim Joerres

Isrid Sturm

Affiliations

Soon will be listed here.

Abstract

Besides amyloidosis and light chain deposition disease, the most common histological type of renal lesion is cast nephropathy in 30% of patients with multiple myeloma [2]. In contrast to amyloidosis, cast nephropathy is believed to be potentially reversible when circulating light chains are rapidly reduced. We report on three patients with multiple myeloma and cast nephropathy treated with a bortezomib-based chemotherapy in addition to a newly developed high-cutoff polyflux® haemofilter. Reduction in serum free light chain levels was achieved within 10-12 days, with all three patients improving their renal function.

Citing Articles

Extracorporeal light-chain elimination in myeloma with simple medium cutoff membrane hemodialysis: a retrospective cohort study.

Schaaf C, Braunisch M, Holzmann-Littig C, Pfister F, Hannemann L, Hausinger R Front Oncol. 2023; 13:1193504.

PMID: 37746285 PMC: 10514899. DOI: 10.3389/fonc.2023.1193504.

Treatment of acute renal failure secondary to multiple myeloma with chemotherapy and extended high cut-off hemodialysis.

Hutchison C, Bradwell A, Cook M, Basnayake K, Basu S, Harding S Clin J Am Soc Nephrol. 2009; 4(4):745-54.

PMID: 19339414 PMC: 2666427. DOI: 10.2215/CJN.04590908.

European trial of free light chain removal by extended haemodialysis in cast nephropathy (EuLITE): a randomised control trial.

Hutchison C, Cook M, Heyne N, Weisel K, Billingham L, Bradwell A Trials. 2008; 9:55.

PMID: 18822172 PMC: 2564897. DOI: 10.1186/1745-6215-9-55.

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