Dissecting Kawasaki Disease: a State-of-the-art Review

Overview

Journal Eur J Pediatr

Specialty Pediatrics

Date 2017 Jun 29

PMID 28656474

Citations 81

Authors

S M Dietz

D van Stijn

D Burgner

M Levin

I M Kuipers

B A Hutten

T W Kuijpers

Affiliations

Soon will be listed here.

Abstract

Conclusion: Many aspects of KD remain unknown, although there is growing knowledge on the etiology, treatment, and development and classification of CAA. Since children with previous KD are entering adulthood, long-term follow-up is increasingly important. What is known: • Kawasaki disease (KD) is a pediatric vasculitis with coronary artery damage as its main complication. • Although KD approaches its 50th birthday since its first description, many aspects of the disease remain poorly understood. What is new: • In recent years, multiple genetic candidate pathways involved in KD have been identified, with recently promising information about the ITPKC pathway. • As increasing numbers of KD patients are reaching adulthood, increasing information is available about the long-term consequences of coronary artery damage and broader cardiovascular risk.

Citing Articles

Fostering Global Collaboration Around Kawasaki Disease. Reflections From the 14th International Kawasaki Disease Symposium.

Tremoulet A, Dahdah N CJC Pediatr Congenit Heart Dis. 2025; 3(6):237-240.

PMID: 39959627 PMC: 11827021. DOI: 10.1016/j.cjcpc.2024.10.004.

A Nomogram Model for Predicting Recurrent Coronary Thrombosis in Kawasaki Disease Patients.

Zhou X, Peng Y, Yi Q J Inflamm Res. 2025; 18():105-114.

PMID: 39780986 PMC: 11705992. DOI: 10.2147/JIR.S473511.

Identification of key ferroptosis‑related biomarkers in Kawasaki disease by clinical and experimental validation.

Yan R, Chen S, Lang X, Liu J, Zhou T Biomed Rep. 2024; 22(1):16.

PMID: 39624783 PMC: 11609609. DOI: 10.3892/br.2024.1894.

mTOR signalling controls the formation of smooth muscle cell-derived luminal myofibroblasts during vasculitis.

Stock A, Parsons S, Hansen J, DSilva D, Starkey G, Fayed A EMBO Rep. 2024; 25(10):4570-4593.

PMID: 39271773 PMC: 11467406. DOI: 10.1038/s44319-024-00251-1.

Exploring the pathogenetic mechanisms of (Review).

Georgakopoulou V, Lempesis I, Sklapani P, Trakas N, Spandidos D Exp Ther Med. 2024; 28(1):271.

PMID: 38765654 PMC: 11097136. DOI: 10.3892/etm.2024.12559.

References

Shrestha S, Wiener H, Olson A, Edberg J, Bowles N, Patel H . Functional FCGR2B gene variants influence intravenous immunoglobulin response in patients with Kawasaki disease. J Allergy Clin Immunol. 2011; 128(3):677-80. PMC: 3444515. DOI: 10.1016/j.jaci.2011.04.027. View

Sanchez-Manubens J, Anton J, Bou R, Iglesias E, Calzada-Hernandez J, Borlan S . Role of the Egami score to predict immunoglobulin resistance in Kawasaki disease among a Western Mediterranean population. Rheumatol Int. 2016; 36(7):905-10. DOI: 10.1007/s00296-016-3499-y. View

Alphonse M, Duong T, Shumitzu C, Hoang T, McCrindle B, Franco A . Inositol-Triphosphate 3-Kinase C Mediates Inflammasome Activation and Treatment Response in Kawasaki Disease. J Immunol. 2016; 197(9):3481-3489. DOI: 10.4049/jimmunol.1600388. View

. Guidelines for diagnosis and management of cardiovascular sequelae in Kawasaki disease (JCS 2013). Digest version. Circ J. 2014; 78(10):2521-62. DOI: 10.1253/circj.cj-66-0096. View

Kawasaki T . [Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children]. Arerugi. 1967; 16(3):178-222. View

Davies S, Sutton N, Blackstock S, Gormley S, Hoggart C, Levin M . Predicting IVIG resistance in UK Kawasaki disease. Arch Dis Child. 2015; 100(4):366-8. DOI: 10.1136/archdischild-2014-307397. View

Tremoulet A, Jain S, Jaggi P, Jimenez-Fernandez S, Pancheri J, Sun X . Infliximab for intensification of primary therapy for Kawasaki disease: a phase 3 randomised, double-blind, placebo-controlled trial. Lancet. 2014; 383(9930):1731-8. DOI: 10.1016/S0140-6736(13)62298-9. View

Tsai F, Lee Y, Chang J, Huang L, Huang F, Chiu N . Identification of novel susceptibility Loci for kawasaki disease in a Han chinese population by a genome-wide association study. PLoS One. 2011; 6(2):e16853. PMC: 3033903. DOI: 10.1371/journal.pone.0016853. View

Hwang J, Lee K, Rhim J, Youn Y, Oh J, Han J . Assessment of intravenous immunoglobulin non-responders in Kawasaki disease. Arch Dis Child. 2010; 96(11):1088-90. DOI: 10.1136/adc.2010.184101. View

10.

Lou J, Xu S, Zou L, Zhong R, Zhang T, Sun Y . A functional polymorphism, rs28493229, in ITPKC and risk of Kawasaki disease: an integrated meta-analysis. Mol Biol Rep. 2012; 39(12):11137-44. DOI: 10.1007/s11033-012-2022-0. View

11.

Nishad P, Singh S, Sidhu M, Malhi P . Cognitive and behaviour assessment following Kawasaki disease--a study from North India. Rheumatol Int. 2009; 30(6):851-4. DOI: 10.1007/s00296-009-1078-1. View

12.

Reth M, Wienands J . Initiation and processing of signals from the B cell antigen receptor. Annu Rev Immunol. 1997; 15:453-79. DOI: 10.1146/annurev.immunol.15.1.453. View

13.

Dionne A, Bakloul M, Manlhiot C, McCrindle B, Hosking M, Houde C . Coronary Artery Bypass Grafting and Percutaneous Coronary Intervention after Kawasaki Disease: The Pediatric Canadian Series. Pediatr Cardiol. 2016; 38(1):36-43. DOI: 10.1007/s00246-016-1480-x. View

14.

Durongpisitkul K, Gururaj V, Park J, Martin C . The prevention of coronary artery aneurysm in Kawasaki disease: a meta-analysis on the efficacy of aspirin and immunoglobulin treatment. Pediatrics. 1995; 96(6):1057-61. View

15.

Onouchi Y, Ozaki K, Burns J, Shimizu C, Terai M, Hamada H . A genome-wide association study identifies three new risk loci for Kawasaki disease. Nat Genet. 2012; 44(5):517-21. DOI: 10.1038/ng.2220. View

16.

Khor C, Davila S, Breunis W, Lee Y, Shimizu C, Wright V . Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. Nat Genet. 2011; 43(12):1241-6. DOI: 10.1038/ng.981. View

17.

Suda K, Iemura M, Nishiono H, Teramachi Y, Koteda Y, Kishimoto S . Long-term prognosis of patients with Kawasaki disease complicated by giant coronary aneurysms: a single-institution experience. Circulation. 2011; 123(17):1836-42. DOI: 10.1161/CIRCULATIONAHA.110.978213. View

18.

Chi H, Huang F, Chen M, Chiu N, Lee H, Lin S . ITPKC gene SNP rs28493229 and Kawasaki disease in Taiwanese children. Hum Mol Genet. 2010; 19(6):1147-51. DOI: 10.1093/hmg/ddp586. View

19.

Akagi T . Interventions in Kawasaki disease. Pediatr Cardiol. 2005; 26(2):206-12. DOI: 10.1007/s00246-004-0964-2. View

20.

Duan J, Lou J, Zhang Q, Ke J, Qi Y, Shen N . A genetic variant rs1801274 in FCGR2A as a potential risk marker for Kawasaki disease: a case-control study and meta-analysis. PLoS One. 2014; 9(8):e103329. PMC: 4122468. DOI: 10.1371/journal.pone.0103329. View