Treatment and Outcome of Metastatic Paraganglioma of the Spine

Overview

Journal Eur Spine J

Specialty Orthopedics

Date 2017 Jun 28

PMID 28653097

Citations 11

Authors

Qi Jia

Huabin Yin

Jian Yang

Zhipeng Wu

Wangjun Yan

Wang Zhou

Xinghai Yang

Jianru Xiao

Affiliations

Soon will be listed here.

Abstract

Background: Spinal metastatic paraganglioma (MPG) is rare and only reported in individual case reports. The low incidence makes it difficult to define appropriate therapy and prognosis. Our study illustrated the largest series to discuss the possible treatment and outcomes of patients with spinal MPG.

Methods: A retrospective study of 15 patients with spinal MPG who were surgically treated between 2005 and 2014 was performed. Three surgical modalities were applied, and radiotherapy and chemotherapy were utilized as adjuvant therapy.

Results: The mean patients age was 40.9 (range 23-58) years. The period between primary surgery and spinal metastasis averaged 8.2 (0.5-15) years. Lesions were mainly located in cervical spine (2), thoracic spine (8), lumbar spine (3), and sacrum (2). The mean follow-up period was 35.0 months. Lesion progression was detected in nine patients, whereas five patients (33.3%) passed away. For solitary spine, multiple bone and both bone and nonosseous metastasis cases, the mean progression-free survival was 41 (range 9-56), 22.5 (range 12-38) and 8.3 (range 3-18) months, respectively.

Conclusions: The cases presented in the current study highlight the crucial role of surgery. Total en bloc for solitary spinal MPG could result in a satisfying prognosis and piecemeal total resection with postoperative radiotherapy could be an alternative therapy. Radiotherapy and chemotherapy were advocated, especially for the multiple metastasis.

Citing Articles

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Spondylectomy in the treatment of neoplastic spinal lesions - A retrospective outcome analysis of 582 patients using a patient-level meta-analysis.

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Surgical Metastasectomy in the Spine: A Review Article.

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Metastatic Paraganglioma of the Spine With Mutation: Case Report and Review of the Literature.

Jabarkheel R, Pendharkar A, Lavezo J, Annes J, Desai K, Vogel H Int J Spine Surg. 2021; 14(s4):S37-S45.

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Liu S, Zhou X, Song A, Huo Z, Li W, Rastogi R Medicine (Baltimore). 2019; 98(39):e17145.

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