Evidence for a Role of Nerve Injury in Painful Intervertebral Disc Degeneration: A Cross-Sectional Proteomic Analysis of Human Cerebrospinal Fluid

Overview

Journal J Pain

Specialties Neurology
Psychiatry

Date 2017 Jun 28

PMID 28652204

Citations 11

Authors

Tony K Y Lim

Kathleen M Anderson

Pawan Hari

Marcos Di Falco

Troy E Reihsen

George L Wilcox

Kumar G Belani

Sylvie LaBoissiere

Manuel R Pinto

David S Beebe

Lois J Kehl

Laura S Stone

Affiliations

Soon will be listed here.

Abstract

Perspective: CSF was examined for differential protein expression in healthy control participants, pain-free adults with asymptomatic intervertebral DD, and LBP patients with painful intervertebral DD. While DD was related to inflammation regardless of pain status, painful degeneration was associated with markers linked to nerve injury.

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