CREB1 Regulates Glucose Transport of Glioma Cell Line U87 by Targeting GLUT1

Overview

Journal Mol Cell Biochem

Publisher Springer

Specialty Biochemistry

Date 2017 Jun 25

PMID 28646353

Citations 13

Authors

Jiaying Chen

Can Zhang

Yang Mi

Fuxue Chen

Dongshu Du

Affiliations

Soon will be listed here.

Abstract

Glioma is stemmed from the glial cells in the brain, which is accounted for about 45% of all intracranial tumors. The characteristic of glioma is invasive growth, as well as there is no obvious boundary between normal brain tissue and glioma tissue, so it is difficult to resect completely with worst prognosis. The metabolism of glioma is following the Warburg effect. Previous researches have shown that GLUT1, as a glucose transporter carrier, affected the Warburg effect, but the molecular mechanism is not very clear. CREB1 (cAMP responsive element-binding protein1) is involved in various biological processes, and relevant studies confirmed that CREB1 protein regulated the expression of GLUT1, thus mediating glucose transport in cells. Our experiments mainly reveal that the CREB1 could affect glucose transport in glioma cells by regulating the expression of GLUT1, which controlled the metabolism of glioma and affected the progression of glioma.

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