Versatility of Presenilin 1

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2017 Jun 25

PMID 28645897

Authors

Georgia R Frost

Eitan Wong

Yue-Ming Li

Affiliations

Soon will be listed here.

References

Zhang Z, Hartmann H, Do V, Abramowski D, Sturchler-Pierrat C, Staufenbiel M . Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature. 1998; 395(6703):698-702. DOI: 10.1038/27208. View

Sherrington R, Rogaev E, Liang Y, Rogaeva E, Levesque G, Ikeda M . Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature. 1995; 375(6534):754-60. DOI: 10.1038/375754a0. View

Bustos V, Pulina M, Kelahmetoglu Y, Sinha S, Gorelick F, Flajolet M . Bidirectional regulation of Aβ levels by Presenilin 1. Proc Natl Acad Sci U S A. 2017; 114(27):7142-7147. PMC: 5502639. DOI: 10.1073/pnas.1705235114. View

Li Y, Xu M, Lai M, Huang Q, Castro J, Harrison T . Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1. Nature. 2000; 405(6787):689-94. DOI: 10.1038/35015085. View

Duff K, Eckman C, Zehr C, Yu X, Prada C, Perez-Tur J . Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature. 1996; 383(6602):710-3. DOI: 10.1038/383710a0. View

Bustos V, Pulina M, Bispo A, Lam A, Flajolet M, Gorelick F . Phosphorylated Presenilin 1 decreases β-amyloid by facilitating autophagosome-lysosome fusion. Proc Natl Acad Sci U S A. 2017; 114(27):7148-7153. PMC: 5502640. DOI: 10.1073/pnas.1705240114. View

Matz A, Halamoda-Kenzaoui B, Hamelin R, Mosser S, Alattia J, Dimitrov M . Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production. J Neurochem. 2014; 133(3):409-21. DOI: 10.1111/jnc.12996. View

Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y . The role of presenilin cofactors in the gamma-secretase complex. Nature. 2003; 422(6930):438-41. DOI: 10.1038/nature01506. View

Harris H, Rubinsztein D . Control of autophagy as a therapy for neurodegenerative disease. Nat Rev Neurol. 2011; 8(2):108-17. DOI: 10.1038/nrneurol.2011.200. View

10.

Maesako M, Horlacher J, Zoltowska K, Kastanenka K, Kara E, Svirsky S . Pathogenic PS1 phosphorylation at Ser367. Elife. 2017; 6. PMC: 5279945. DOI: 10.7554/eLife.19720. View

11.

De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert W . Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature. 1998; 391(6665):387-90. DOI: 10.1038/34910. View

12.

Tian Y, Chang J, Fan E, Flajolet M, Greengard P . Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy. Proc Natl Acad Sci U S A. 2013; 110(42):17071-6. PMC: 3801056. DOI: 10.1073/pnas.1315110110. View

13.

Lai M, Chen E, Crouthamel M, DiMuzio-Mower J, Xu M, Huang Q . Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities. J Biol Chem. 2003; 278(25):22475-81. DOI: 10.1074/jbc.M300974200. View

14.

Ahn K, Shelton C, Tian Y, Zhang X, Gilchrist M, Sisodia S . Activation and intrinsic gamma-secretase activity of presenilin 1. Proc Natl Acad Sci U S A. 2010; 107(50):21435-40. PMC: 3003001. DOI: 10.1073/pnas.1013246107. View

15.

Thinakaran G, Borchelt D, Lee M, Slunt H, Spitzer L, Kim G . Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron. 1996; 17(1):181-90. DOI: 10.1016/s0896-6273(00)80291-3. View

16.

Wolfe M, Xia W, Ostaszewski B, Diehl T, Kimberly W, Selkoe D . Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature. 1999; 398(6727):513-7. DOI: 10.1038/19077. View

17.

Naruse S, Thinakaran G, Luo J, Kusiak J, Tomita T, Iwatsubo T . Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron. 1998; 21(5):1213-21. DOI: 10.1016/s0896-6273(00)80637-6. View

18.

Nilsson P, Saido T . Dual roles for autophagy: degradation and secretion of Alzheimer's disease Aβ peptide. Bioessays. 2014; 36(6):570-8. PMC: 4316186. DOI: 10.1002/bies.201400002. View

19.

Xia D, Watanabe H, Wu B, Lee S, Li Y, Tsvetkov E . Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease. Neuron. 2015; 85(5):967-81. PMC: 4358812. DOI: 10.1016/j.neuron.2015.02.010. View

20.

Nixon R . The role of autophagy in neurodegenerative disease. Nat Med. 2013; 19(8):983-97. DOI: 10.1038/nm.3232. View