» Articles » PMID: 28638365

Motor Impairments in Transient Ischemic Attack Increase the Odds of a Subsequent Stroke: A Meta-Analysis

Overview
Journal Front Neurol
Specialty Neurology
Date 2017 Jun 23
PMID 28638365
Citations 10
Authors
Affiliations
Soon will be listed here.
Abstract

Background And Purpose: Transient ischemic attack (TIA) increases the risk for a subsequent stroke. Typical symptoms include motor weakness, gait disturbance, and loss of coordination. The association between the presence of motor impairments during a TIA and the chances of a subsequent stroke has not been examined. In the current meta-analysis, we examine whether the odds of a stroke are greater in TIA individuals who experience motor impairments as compared with those who do not experience motor impairments.

Methods: We conducted a systematic search of electronic databases as well as manual searches of the reference lists of retrieved articles. The meta-analysis included studies that reported an odds ratio relating motor impairments to a subsequent stroke, or the number of individuals with or without motor impairments who experienced a subsequent stroke. We examined these studies using rigorous meta-analysis techniques including random effects model, forest and funnel plots, , publication bias, and fail-safe analysis.

Results: Twenty-four studies with 15,129 participants from North America, Australia, Asia, and Europe qualified for inclusion. An odds ratio of 2.11 (95% CI, 1.67-2.65,  = 0.000) suggested that the chances of a subsequent stroke are increased by twofolds in individuals who experience motor impairments during a TIA compared with those individuals who have no motor impairments.

Conclusion: The presence of motor impairments during TIA is a significantly high-risk clinical characteristic for a subsequent stroke. The current evidence for motor impairments following TIA relies exclusively on the clinical reports of unilateral motor weakness. A comprehensive examination of motor impairments in TIA will enhance TIA prognosis and restoration of residual motor impairments.

Citing Articles

Dynamic and Rapid Detection of Guanosine during Ischemia.

Weese-Myers M, Cryan M, Witt C, Caldwell K, Modi B, Ross A ACS Chem Neurosci. 2023; 14(9):1646-1658.

PMID: 37040534 PMC: 10265669. DOI: 10.1021/acschemneuro.3c00048.


Altered Effective Connectivity of the Primary Motor Cortex in Transient Ischemic Attack.

Hao Z, Song Y, Shi Y, Xi H, Zhang H, Zhao M Neural Plast. 2022; 2022:2219993.

PMID: 36437903 PMC: 9699783. DOI: 10.1155/2022/2219993.


Recent advances in the management of transient ischemic attacks.

Ortiz-Garcia J, Gomez C, Schneck M, Biller J Fac Rev. 2022; 11:19.

PMID: 35949262 PMC: 9340656. DOI: 10.12703/r/11-19.


Multiple Mild Stimulations Reduce Membrane Distribution of CX3CR1 Promoted by Annexin a1 in Microglia to Attenuate Excessive Dendritic Spine Pruning and Cognitive Deficits Caused by a Transient Ischemic Attack in Mice.

Zheng L, Wang Y, Shao B, Zhou H, Li X, Zhang C Neurosci Bull. 2022; 38(7):753-768.

PMID: 35352285 PMC: 9276903. DOI: 10.1007/s12264-022-00847-4.


Quantifying changes over 1 year in motor and cognitive skill after transient ischemic attack (TIA) using robotics.

Simmatis L, Scott S, Jin A Sci Rep. 2021; 11(1):17011.

PMID: 34426586 PMC: 8382836. DOI: 10.1038/s41598-021-96177-y.


References
1.
Ay H, Arsava E, Johnston S, Vangel M, Schwamm L, Furie K . Clinical- and imaging-based prediction of stroke risk after transient ischemic attack: the CIP model. Stroke. 2008; 40(1):181-6. DOI: 10.1161/STROKEAHA.108.521476. View

2.
Sorensen A, Ay H . Transient ischemic attack: definition, diagnosis, and risk stratification. Neuroimaging Clin N Am. 2011; 21(2):303-13, x. PMC: 3109304. DOI: 10.1016/j.nic.2011.01.013. View

3.
Jove M, Mauri-Capdevila G, Suarez I, Cambray S, Sanahuja J, Quilez A . Metabolomics predicts stroke recurrence after transient ischemic attack. Neurology. 2014; 84(1):36-45. PMC: 4336096. DOI: 10.1212/WNL.0000000000001093. View

4.
Park K, Youn Y, Chung C, Lee K, Kim G, Chung P . Large-artery stenosis predicts subsequent vascular events in patients with transient ischemic attack. J Clin Neurol. 2009; 3(4):169-74. PMC: 2686947. DOI: 10.3988/jcn.2007.3.4.169. View

5.
Colebatch J, Gandevia S . The distribution of muscular weakness in upper motor neuron lesions affecting the arm. Brain. 1989; 112 ( Pt 3):749-63. DOI: 10.1093/brain/112.3.749. View