The Association Between Various Smoking Behaviors, Cotinine Biomarkers and Skin Autofluorescence, a Marker for Advanced Glycation End Product Accumulation

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2017 Jun 21

PMID 28632785

Citations 19

Authors

Robert P van Waateringe

Marjonneke J Mook-Kanamori

Sandra N Slagter

Melanie M van der Klauw

Jana V van Vliet-Ostaptchouk

Reindert Graaff

Helen L Lutgers

Karsten Suhre

Mohammed M El-Din Selim

Dennis O Mook-Kanamori

Bruce H R Wolffenbuttel

Affiliations

Soon will be listed here.

Abstract

Background: Skin autofluorescence, a biomarker for advanced glycation end products (AGEs) accumulation, has been shown to predict diabetes-related cardiovascular complications and is associated with several environmental and lifestyle factors. In the present study, we examined the association between various smoking behaviors and skin autofluorescence, as well as the association between several cotinine biomarkers and skin autofluorescence, using both epidemiological and metabolomics data.

Methods: In a cross-sectional study, we evaluated participants from the LifeLines Cohort Study and the Qatar Metabolomics Study on Diabetes (QMDiab). In the LifeLines Cohort Study smoking behavior and secondhand smoking were assessed in 8,905 individuals including 309 individuals (3.5%) with type 2 diabetes. In QMDiab, cotinine biomarkers were measured in saliva, plasma and urine in 364 individuals of whom 188 (51%) had type 2 diabetes. Skin autofluorescence was measured non-invasively in all participants using the AGE Reader.

Results: Skin autofluorescence levels increased with a higher number of hours being exposed to secondhand smoking. Skin autofluorescence levels of former smokers approached levels of never smokers after around 15 years of smoking cessation. Urinary cotinine N-oxide, a biomarker of nicotine exposure, was found to be positively associated with skin autofluorescence in the QMDiab study (p = 0.03).

Conclusions: In the present study, we have demonstrated that secondhand smoking is associated with higher skin autofluorescence levels whereas smoking cessation has a beneficial effect on skin autofluorescence. Finally, urinary cotinine N-oxide might be used as an alternative way for questionnaires to examine the effect of (environmental) tobacco smoking on skin autofluorescence.

Citing Articles

Association Between Skin Autofluorescence and Coronary Heart Disease in Chinese General Population: A Cross-Sectional Study.

Wu Q, Cheng Y, Liu H, Wang Y, Li B, Mu Y J Diabetes. 2025; 17(3):e70061.

PMID: 40024885 PMC: 11872386. DOI: 10.1111/1753-0407.70061.

Association between Mediterranean Diet and Advanced Glycation End Products in University Students: A Cross-Sectional Study.

Polic N, Matulic V, Dragun T, Matek H, Marendic M, Efendic I Nutrients. 2024; 16(15).

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Comment on Peker, T.; Boyraz, B. The Relationship between Resistant Hypertension and Advanced Glycation End-Product Levels Measured Using the Skin Autofluorescence Method: A Case-Control Study. 2023, , 6606.

Alkhami F, Foussard N, Larroumet A, Barbet-Massin M, Blanco L, Mohammedi K J Clin Med. 2023; 12(24).

PMID: 38137634 PMC: 10744274. DOI: 10.3390/jcm12247562.

Advanced glycation end products: Key mediator and therapeutic target of cardiovascular complications in diabetes.

Bansal S, Burman A, Tripathi A World J Diabetes. 2023; 14(8):1146-1162.

PMID: 37664478 PMC: 10473940. DOI: 10.4239/wjd.v14.i8.1146.

Research Trends in Advanced Glycation End Products and Obesity: Bibliometric Analysis.

Liman P, Anastasya K, Salma N, Yenny Y, Faradilla M Nutrients. 2022; 14(24).

PMID: 36558414 PMC: 9783605. DOI: 10.3390/nu14245255.

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