Biomarkers to Detect Rejection After Kidney Transplantation

Overview

Journal Pediatr Nephrol

Specialties Nephrology
Pediatrics

Date 2017 Jun 21

PMID 28631040

Citations 8

Authors

Vikas R Dharnidharka

Andrew Malone

Affiliations

Soon will be listed here.

Abstract

Detecting acute rejection in kidney transplantation has been traditionally done using histological analysis of invasive allograft biopsies, but this method carries a risk and is not perfect. Transplant professionals have been working to develop more accurate or less invasive biomarkers that can predict acute rejection or subsequent worse allograft survival. These biomarkers can use tissue, blood or urine as a source. They can comprise individual molecules or panels, singly or in combination, across different components or pathways of the immune system. This review highlights the most recent evidence for biomarker efficacy, especially from multicenter trials.

Citing Articles

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Biomarkers of alloimmune events in pediatric kidney transplantation.

Deville K, Seifert M Front Pediatr. 2023; 10:1087841.

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Molecular Markers of Kidney Transplantation Outcome: Current Omics Tools and Future Developments.

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New Insights from Metabolomics in Pediatric Renal Diseases.

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Challenges of Diagnosing Antibody-Mediated Rejection: The Role of Invasive and Non-Invasive Biomarkers.

Krishnamoorthy S, Kyeso Y Medicina (Kaunas). 2021; 57(5).

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