Discriminating Value of Calprotectin in Disease Activity and Progression of Nonradiographic Axial Spondyloarthritis and Ankylosing Spondylitis

Overview

Journal Dis Markers

Publisher Wiley

Specialty Biochemistry

Date 2017 Jun 21

PMID 28630526

Citations 4

Authors

Jinxian Huang

Zhihua Yin

Guoxiang Song

Shengjin Cui

Jinzhao Jiang

Lijun Zhang

Affiliations

Soon will be listed here.

Abstract

It has been controversial whether ankylosing spondylitis (AS) and nonradiographic axial spondyloarthritis (nr-axSpA) are separate or different phases of radiographic progression. We determined that serum calprotectin level (ng/ml) was higher in AS (15.30 ± 6.49) and nr-axSpA (17.76 ± 8.59) patients than in healthy individuals (7.40 ± 2.67). No difference was observed in calprotectin level between these two groups. Elevated calprotectin was positively correlated with ESR, CRP, BASDAI, and ASDAS as well as SPARCC scoring and had no correlation with BASFI and mSASSS. No correlation was observed between calprotectin and Wnt/-catenin pathway markers. Serum calprotectin can be used as a marker for inflammation in both nr-axSpA and AS, while it does not contribute to the discrimination of AS and nr-axSpA. Calprotectin-mediated inflammation was not correlated with principle effectors of Wnt/-catenin pathway, indicating that inflammation and bone fusion might be separate processes of the disease.

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References

Daoussis D, Liossis S, Solomou E, Tsanaktsi A, Bounia K, Karampetsou M . Evidence that Dkk-1 is dysfunctional in ankylosing spondylitis. Arthritis Rheum. 2009; 62(1):150-8. DOI: 10.1002/art.27231. View

Poddubnyy D, Sieper J . Similarities and differences between nonradiographic and radiographic axial spondyloarthritis: a clinical, epidemiological and therapeutic assessment. Curr Opin Rheumatol. 2014; 26(4):377-83. DOI: 10.1097/BOR.0000000000000071. View

van Lent P, Grevers L, Blom A, Sloetjes A, Mort J, Vogl T . Myeloid-related proteins S100A8/S100A9 regulate joint inflammation and cartilage destruction during antigen-induced arthritis. Ann Rheum Dis. 2007; 67(12):1750-8. DOI: 10.1136/ard.2007.077800. View

Rudwaleit M, van der Heijde D, Landewe R, Listing J, Akkoc N, Brandt J . The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection. Ann Rheum Dis. 2009; 68(6):777-83. DOI: 10.1136/ard.2009.108233. View

Duan L, Wu R, Ye L, Wang H, Yang X, Zhang Y . S100A8 and S100A9 are associated with colorectal carcinoma progression and contribute to colorectal carcinoma cell survival and migration via Wnt/β-catenin pathway. PLoS One. 2013; 8(4):e62092. PMC: 3637369. DOI: 10.1371/journal.pone.0062092. View

Rudwaleit M, van der Heijde D, Landewe R, Akkoc N, Brandt J, Chou C . The Assessment of SpondyloArthritis International Society classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general. Ann Rheum Dis. 2010; 70(1):25-31. DOI: 10.1136/ard.2010.133645. View

Ehrchen J, Sunderkotter C, Foell D, Vogl T, Roth J . The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer. J Leukoc Biol. 2009; 86(3):557-66. DOI: 10.1189/jlb.1008647. View

Viemann D, Strey A, Janning A, Jurk K, Klimmek K, Vogl T . Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells. Blood. 2004; 105(7):2955-62. DOI: 10.1182/blood-2004-07-2520. View

van den Bosch M, Blom A, Schelbergen R, Vogl T, Roth J, Sloetjes A . Induction of Canonical Wnt Signaling by the Alarmins S100A8/A9 in Murine Knee Joints: Implications for Osteoarthritis. Arthritis Rheumatol. 2015; 68(1):152-63. DOI: 10.1002/art.39420. View

10.

van der Linden S, VALKENBURG H, Cats A . Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum. 1984; 27(4):361-8. DOI: 10.1002/art.1780270401. View

11.

Klingberg E, Carlsten H, Hilme E, Hedberg M, Forsblad-dElia H . Calprotectin in ankylosing spondylitis--frequently elevated in feces, but normal in serum. Scand J Gastroenterol. 2012; 47(4):435-44. DOI: 10.3109/00365521.2011.648953. View

12.

Vogl T, Ludwig S, Goebeler M, Strey A, Thorey I, Reichelt R . MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes. Blood. 2004; 104(13):4260-8. DOI: 10.1182/blood-2004-02-0446. View

13.

Turina M, Sieper J, Yeremenko N, Conrad K, Haibel H, Rudwaleit M . Calprotectin serum level is an independent marker for radiographic spinal progression in axial spondyloarthritis. Ann Rheum Dis. 2014; 73(9):1746-8. DOI: 10.1136/annrheumdis-2014-205506. View

14.

Ustun N, Tok F, Kalyoncu U, Motor S, Yuksel R, Yagiz A . Sclerostin and Dkk-1 in patients with ankylosing spondylitis. Acta Reumatol Port. 2014; 39(2):146-51. View

15.

Wendling D, Verhoeven F, Prati C . Calprotectin and spondyloarthritis. Expert Rev Clin Immunol. 2017; 13(4):295-296. DOI: 10.1080/1744666X.2017.1285700. View

16.

Yucong Z, Lu L, Shengfa L, Yongliang Y, Ruguo S, Yikai L . Serum functional dickkopf-1 levels are inversely correlated with radiographic severity of ankylosing spondylitis. Clin Lab. 2014; 60(9):1527-31. DOI: 10.7754/clin.lab.2014.131119. View

17.

Hu Z, Xu M, Li Q, Lin Z, Liao Z, Cao S . Adalimumab significantly reduces inflammation and serum DKK-1 level but increases fatty deposition in lumbar spine in active ankylosing spondylitis. Int J Rheum Dis. 2012; 15(4):358-65. DOI: 10.1111/j.1756-185X.2012.01734.x. View

18.

Kwon S, Lim M, Suh C, Park S, Hong Y, Yoon B . Dickkopf-1 level is lower in patients with ankylosing spondylitis than in healthy people and is not influenced by anti-tumor necrosis factor therapy. Rheumatol Int. 2011; 32(8):2523-7. DOI: 10.1007/s00296-011-1981-0. View

19.

Uderhardt S, Diarra D, Katzenbeisser J, David J, Zwerina J, Richards W . Blockade of Dickkopf (DKK)-1 induces fusion of sacroiliac joints. Ann Rheum Dis. 2009; 69(3):592-7. DOI: 10.1136/ard.2008.102046. View

20.

Creemers M, Franssen M, vant Hof M, Gribnau F, van de Putte L, Van Riel P . Assessment of outcome in ankylosing spondylitis: an extended radiographic scoring system. Ann Rheum Dis. 2004; 64(1):127-9. PMC: 1755183. DOI: 10.1136/ard.2004.020503. View