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The Molecular Pathogenesis of the NUP98-HOXA9 Fusion Protein in Acute Myeloid Leukemia

Overview
Journal Leukemia
Specialties Hematology
Oncology
Date 2017 Jun 21
PMID 28630438
Citations 22
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References
1.
Baker A, Gregory G, Verbrugge I, Kats L, Hilton J, Vidacs E . The CDK9 Inhibitor Dinaciclib Exerts Potent Apoptotic and Antitumor Effects in Preclinical Models of MLL-Rearranged Acute Myeloid Leukemia. Cancer Res. 2015; 76(5):1158-69. DOI: 10.1158/0008-5472.CAN-15-1070. View

2.
Anne M, Sammartino D, Barginear M, Budman D . Profile of panobinostat and its potential for treatment in solid tumors: an update. Onco Targets Ther. 2013; 6:1613-24. PMC: 3833618. DOI: 10.2147/OTT.S30773. View

3.
Xu H, Valerio D, Eisold M, Sinha A, Koche R, Hu W . NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis. Cancer Cell. 2016; 30(6):863-878. PMC: 5501282. DOI: 10.1016/j.ccell.2016.10.019. View

4.
Takeda A, Goolsby C, Yaseen N . NUP98-HOXA9 induces long-term proliferation and blocks differentiation of primary human CD34+ hematopoietic cells. Cancer Res. 2006; 66(13):6628-37. DOI: 10.1158/0008-5472.CAN-06-0458. View

5.
Bots M, Verbrugge I, Martin B, Salmon J, Ghisi M, Baker A . Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors. Blood. 2014; 123(9):1341-52. PMC: 3938147. DOI: 10.1182/blood-2013-03-488114. View