Iscador Qu Inhibits Doxorubicin-induced Senescence of MCF7 Cells

Overview

Journal Sci Rep

Specialty Science

Date 2017 Jun 21

PMID 28630419

Citations 9

Authors

Tatjana Srdic-Rajic

Juan F Santibanez

Ksenija Kanjer

Nevena Tisma-Miletic

Milena Cavic

Daniel Galun

Marko Jevric

Nevena Kardum

Aleksandra Konic-Ristic

Tamara Zoranovic

Affiliations

Soon will be listed here.

Abstract

Chemotherapy in patients with inoperable or advanced breast cancer inevitably results in low-dose exposure of tumor-cell subset and senescence. Metabolically active senescent cells secrete multiple tumor promoting factors making their elimination a therapeutic priority. Viscum album is one of the most widely used alternative anti-cancer medicines facilitating chemotherapy tolerance of breast cancer patients. The aim of this study was to model and investigate how Viscum album extracts execute additive anti-tumor activity with low-dose Dox using ER + MCF7 breast cancer cells. We report that cotreatment of MCF7 with Viscum album and Dox abrogates G2/M cycle arrest replacing senescence with intrinsic apoptotic program. Mechanistically, this switch was associated with down-regulation of p21, p53/p73 as well as Erk1/2 and p38 activation. Our findings, therefore, identify a novel mechanistic axis of additive antitumor activity of Viscum album and low dose-Dox. In conclusion, ER + breast cancer patients may benefit from addition of Viscum album to low-dose Dox chemotherapy due to suppression of cancer cell senescence and induction of apoptosis.

Citing Articles

Antitumor Effect of Iscador on Breast Cancer Cell Lines with Different Metastatic Potential.

Robev B, Iliev I, Tsoneva I, Momchilova A, Nesheva A, Kostadinova A Int J Mol Sci. 2023; 24(6).

PMID: 36982323 PMC: 10049140. DOI: 10.3390/ijms24065247.

Nutrition Interventions of Herbal Compounds on Cellular Senescence.

Chen Z, Wu Y, Lin Q, Cai J, Liu X, Liang Y Oxid Med Cell Longev. 2022; 2022:1059257.

PMID: 35528514 PMC: 9068308. DOI: 10.1155/2022/1059257.

The Impacts of Prepared Plasma-Activated Medium (PAM) Combined with Doxorubicin on the Viability of MCF-7 Breast Cancer Cells: A New Cancer Treatment Strategy.

Zahedian S, Hekmat A, Tackallou S, Ghoranneviss M Rep Biochem Mol Biol. 2022; 10(4):640-652.

PMID: 35291609 PMC: 8903366. DOI: 10.52547/rbmb.10.4.640.

Thymoquinone and Costunolide Induce Apoptosis of Both Proliferative and Doxorubicin-Induced-Senescent Colon and Breast Cancer Cells.

El-Far A, Godugu K, Noreldin A, Saddiq A, Almaghrabi O, Al Jaouni S Integr Cancer Ther. 2021; 20:15347354211035450.

PMID: 34490824 PMC: 8427913. DOI: 10.1177/15347354211035450.

Functional Fine-Tuning of Metabolic Pathways by the Endocannabinoid System-Implications for Health and Disease.

Moreno E, Cavic M, Canela E Int J Mol Sci. 2021; 22(7).

PMID: 33915889 PMC: 8036872. DOI: 10.3390/ijms22073661.

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