[Prevalence of Osteoporosis, Estimation of Probability of Fracture and Bone Metabolism Study in Patients with Newly Diagnosed Prostate Cancer in the Health Area of Lugo]

Overview

Journal Aten Primaria

Specialty Public Health

Date 2017 Jun 21

PMID 28629885

Authors

Jonatan Miguel-Carrera

Carlos Garcia-Porrua

Francisco Javier de Toro Santos

Jose Antonio Picallo-Sanchez

Affiliations

Soon will be listed here.

Abstract

Objective: To study the prevalence of osteoporosis and fracture probability in patients diagnosed with prostate cancer.

Design: Observational descriptive transversal study. SITE: Study performed from Primary Care of Lugo in collaboration with Rheumatology and Urology Services of our referral hospital.

Participants: Patients diagnosed with prostate cancer without bone metastatic disease from January to December 2012.

Main Measurements: Epidemiologic, clinical, laboratory and densitometric variables involved in osteoporosis were collected. The likelihood of fracture was estimated by FRAX Tool.

Results: Eighty-three patients met the inclusion criteria. None was excluded. The average age was 67 years. The Body Mass Index was 28.28. Twenty-five patients (30.1%) had previous osteoporotic fractures. Other prevalent risk factors were alcohol (26.5%) and smoking (22.9%). Eighty-two subjects had vitamin D below normal level (98.80%). Femoral Neck densitometry showed that 8.9% had osteoporosis and 54% osteopenia. The average fracture risk in this population, estimated by FRAX, was 2.63% for hip fracture and 5.28% for major fracture. Cut level for FRAX major fracture value without DXA >5% and ≥7.5% proposed by Azagra et al. showed 24 patients (28.92%) and 8 patients (9.64%) respectively.

Conclusions: The prevalence of osteoporosis in this population was very high. The more frequent risk factors associated with osteoporosis were: previous osteoporotic fracture, alcohol consumption, smoking and family history of previous fracture. The probability of fracture using femoral neck FRAX tool was low. Vitamin D deficiency was very common (98.8%).

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