Cyp2c44-mediated Decrease of 15-HETE Exacerbates Pulmonary Hypertension

Overview

Journal Am J Physiol Heart Circ Physiol

Publisher American Physiological Society

Specialties Cardiology & Vascular Diseases
Physiology

Date 2017 Jun 20

PMID 28626080

Authors

Gabor A Fulop

Andriy Yabluchanskiy

Affiliations

Soon will be listed here.

References

Bowers R, Cool C, Murphy R, Tuder R, Hopken M, Flores S . Oxidative stress in severe pulmonary hypertension. Am J Respir Crit Care Med. 2004; 169(6):764-9. DOI: 10.1164/rccm.200301-147OC. View

Hoeper M, Ghofrani H, Grunig E, Klose H, Olschewski H, Rosenkranz S . Pulmonary Hypertension. Dtsch Arztebl Int. 2017; 114(5):73-84. PMC: 5331483. DOI: 10.3238/arztebl.2017.0073. View

Zhang B, Naik J, Jernigan N, Walker B, Resta T . Reduced membrane cholesterol limits pulmonary endothelial Ca entry after chronic hypoxia. Am J Physiol Heart Circ Physiol. 2017; 312(6):H1176-H1184. PMC: 5495930. DOI: 10.1152/ajpheart.00097.2017. View

Patel D, Alhawaj R, Kelly M, Accarino J, Lakhkar A, Gupte S . Potential role of mitochondrial superoxide decreasing ferrochelatase and heme in coronary artery soluble guanylate cyclase depletion by angiotensin II. Am J Physiol Heart Circ Physiol. 2016; 310(11):H1439-47. PMC: 4935518. DOI: 10.1152/ajpheart.00859.2015. View

Wang W, Zhang C, Lin D, Wang L, Graves J, Zeldin D . Cyp2c44 epoxygenase in the collecting duct is essential for the high K+ intake-induced antihypertensive effect. Am J Physiol Renal Physiol. 2014; 307(4):F453-60. PMC: 4137132. DOI: 10.1152/ajprenal.00123.2014. View

de Raaf M, Herrmann F, Schalij I, de Man F, Vonk-Noordegraaf A, Guignabert C . Tyrosine kinase inhibitor BIBF1000 does not hamper right ventricular pressure adaptation in rats. Am J Physiol Heart Circ Physiol. 2016; 311(3):H604-12. DOI: 10.1152/ajpheart.00656.2015. View

DeLozier T, Tsao C, Coulter S, Foley J, Bradbury J, Zeldin D . CYP2C44, a new murine CYP2C that metabolizes arachidonic acid to unique stereospecific products. J Pharmacol Exp Ther. 2004; 310(3):845-54. DOI: 10.1124/jpet.104.067819. View

Hoeper M, Humbert M, Souza R, Idrees M, Kawut S, Sliwa-Hahnle K . A global view of pulmonary hypertension. Lancet Respir Med. 2016; 4(4):306-22. DOI: 10.1016/S2213-2600(15)00543-3. View

Chettimada S, Joshi S, Alzoubi A, Gebb S, McMurtry I, Gupte R . Glucose-6-phosphate dehydrogenase plays a critical role in hypoxia-induced CD133+ progenitor cells self-renewal and stimulates their accumulation in the lungs of pulmonary hypertensive rats. Am J Physiol Lung Cell Mol Physiol. 2014; 307(7):L545-56. PMC: 7199226. DOI: 10.1152/ajplung.00303.2013. View

10.

Davis C, Ammi A, Alkayed N, Kaul S . Ultrasound stimulates formation and release of vasoactive compounds in brain endothelial cells. Am J Physiol Heart Circ Physiol. 2015; 309(4):H583-91. PMC: 4537941. DOI: 10.1152/ajpheart.00690.2014. View

11.

Lakhkar A, Dhagia V, Joshi S, Gotlinger K, Patel D, Sun D . 20-HETE-induced mitochondrial superoxide production and inflammatory phenotype in vascular smooth muscle is prevented by glucose-6-phosphate dehydrogenase inhibition. Am J Physiol Heart Circ Physiol. 2016; 310(9):H1107-17. PMC: 4867393. DOI: 10.1152/ajpheart.00961.2015. View

12.

Chester A, Yacoub M . The role of endothelin-1 in pulmonary arterial hypertension. Glob Cardiol Sci Pract. 2014; 2014(2):62-78. PMC: 4220438. DOI: 10.5339/gcsp.2014.29. View

13.

Visovatti S, Hyman M, Goonewardena S, Anyanwu A, Kanthi Y, Robichaud P . Purinergic dysregulation in pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2016; 311(1):H286-98. PMC: 4967198. DOI: 10.1152/ajpheart.00572.2015. View

14.

Montani D, Perros F, Gambaryan N, Girerd B, Dorfmuller P, Price L . C-kit-positive cells accumulate in remodeled vessels of idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med. 2011; 184(1):116-23. DOI: 10.1164/rccm.201006-0905OC. View

15.

Davie N, Crossno Jr J, Frid M, Hofmeister S, Reeves J, Hyde D . Hypoxia-induced pulmonary artery adventitial remodeling and neovascularization: contribution of progenitor cells. Am J Physiol Lung Cell Mol Physiol. 2003; 286(4):L668-78. DOI: 10.1152/ajplung.00108.2003. View

16.

Hassoun P, Mouthon L, Barbera J, Eddahibi S, Flores S, Grimminger F . Inflammation, growth factors, and pulmonary vascular remodeling. J Am Coll Cardiol. 2009; 54(1 Suppl):S10-S19. DOI: 10.1016/j.jacc.2009.04.006. View

17.

Awad K, West J, De Jesus Perez V, MacLean M . Novel signaling pathways in pulmonary arterial hypertension (2015 Grover Conference Series). Pulm Circ. 2016; 6(3):285-94. PMC: 5019081. DOI: 10.1086/688034. View

18.

Farha S, Asosingh K, Xu W, Sharp J, George D, Comhair S . Hypoxia-inducible factors in human pulmonary arterial hypertension: a link to the intrinsic myeloid abnormalities. Blood. 2011; 117(13):3485-93. PMC: 3072874. DOI: 10.1182/blood-2010-09-306357. View

19.

Asosingh K, Aldred M, Vasanji A, Drazba J, Sharp J, Farver C . Circulating angiogenic precursors in idiopathic pulmonary arterial hypertension. Am J Pathol. 2008; 172(3):615-27. PMC: 2258264. DOI: 10.2353/ajpath.2008.070705. View

20.

Toshner M, Voswinckel R, Southwood M, Al-Lamki R, Howard L, Marchesan D . Evidence of dysfunction of endothelial progenitors in pulmonary arterial hypertension. Am J Respir Crit Care Med. 2009; 180(8):780-7. PMC: 2778151. DOI: 10.1164/rccm.200810-1662OC. View