Near-infrared Fluorescence Lymphatic Imaging of Klippel-Trénaunay Syndrome

Overview

Journal J Vasc Surg Venous Lymphat Disord

Specialties Cardiology & Vascular Diseases
General Surgery

Date 2017 Jun 19

PMID 28623992

Citations 3

Authors

John C Rasmussen

Rodrick C Zvavanjanja

Melissa B Aldrich

Matthew R Greives

Eva M Sevick-Muraca

Affiliations

Soon will be listed here.

Abstract

The relationship between lymphatic and venous malformations in Klippel-Trénaunay syndrome is difficult to assess. Herein the authors describe near-infrared fluorescence lymphatic imaging to assess the lymphatics of a subject with a large port-wine stain and right leg edema. Although lymphatic vessels in the medial, affected knee appeared dilated and perhaps tortuous, no definitive abnormal lymphatic pooling or propulsion was observed. The lymphatics in the affected limb were well defined but less numerous than in the contralateral limb, and active, contractile function was observed in all vessels. As demonstrated, near-infrared fluorescence lymphatic imaging enables the clinical assessment of lymphatics in lymphovenous malformations.

Citing Articles

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Degradation of lymphatic anatomy and function in early venous insufficiency.

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Assessing lymphatic route of CSF outflow and peripheral lymphatic contractile activity during head-down tilt using near-infrared fluorescence imaging.

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References

Itkin M, McCormack F, Dori Y . Diagnosis and Treatment of Lymphatic Plastic Bronchitis in Adults Using Advanced Lymphatic Imaging and Percutaneous Embolization. Ann Am Thorac Soc. 2016; 13(10):1689-1696. DOI: 10.1513/AnnalsATS.201604-292OC. View

Sevick-Muraca E, Kwon S, Rasmussen J . Emerging lymphatic imaging technologies for mouse and man. J Clin Invest. 2014; 124(3):905-14. PMC: 3938259. DOI: 10.1172/JCI71612. View

Rasmussen J, Fife C, Sevick-Muraca E . Near-Infrared Fluorescence Lymphatic Imaging in Lymphangiomatosis. Lymphat Res Biol. 2015; 13(3):195-201. PMC: 4575506. DOI: 10.1089/lrb.2015.0013. View

Liu N, Lu Q, Yan Z . Lymphatic malformation is a common component of Klippel-Trenaunay syndrome. J Vasc Surg. 2010; 52(6):1557-63. DOI: 10.1016/j.jvs.2010.06.166. View

Flors L, Leiva-Salinas C, Maged I, Norton P, Matsumoto A, Angle J . MR imaging of soft-tissue vascular malformations: diagnosis, classification, and therapy follow-up. Radiographics. 2011; 31(5):1321-40. DOI: 10.1148/rg.315105213. View

Bastarrika G, Redondo P, Sierra A, Cano D, Martinez-Cuesta A, Lopez-Gutierrez J . New techniques for the evaluation and therapeutic planning of patients with Klippel-Trénaunay syndrome. J Am Acad Dermatol. 2006; 56(2):242-9. DOI: 10.1016/j.jaad.2006.08.057. View

Rasmussen J, Tan I, Marshall M, Adams K, Kwon S, Fife C . Human Lymphatic Architecture and Dynamic Transport Imaged Using Near-infrared Fluorescence. Transl Oncol. 2010; 3(6):362-72. PMC: 3000461. DOI: 10.1593/tlo.10190. View

Rasmussen J, Tan I, Marshall M, Fife C, Sevick-Muraca E . Lymphatic imaging in humans with near-infrared fluorescence. Curr Opin Biotechnol. 2009; 20(1):74-82. PMC: 2692490. DOI: 10.1016/j.copbio.2009.01.009. View

Rasmussen J, Aldrich M, Tan I, Darne C, Zhu B, ODonnell Jr T . Lymphatic transport in patients with chronic venous insufficiency and venous leg ulcers following sequential pneumatic compression. J Vasc Surg Venous Lymphat Disord. 2016; 4(1):9-17. PMC: 4782606. DOI: 10.1016/j.jvsv.2015.06.001. View

10.

Maari C, Frieden I . Klippel-Trénaunay syndrome: the importance of "geographic stains" in identifying lymphatic disease and risk of complications. J Am Acad Dermatol. 2004; 51(3):391-8. DOI: 10.1016/j.jaad.2003.12.017. View

11.

Witte C, Witte M, Unger E, Williams W, Bernas M, McNeill G . Advances in imaging of lymph flow disorders. Radiographics. 2000; 20(6):1697-719. DOI: 10.1148/radiographics.20.6.g00nv141697. View

12.

Burrows P, Gonzalez-Garay M, Rasmussen J, Aldrich M, Guilliod R, Maus E . Lymphatic abnormalities are associated with RASA1 gene mutations in mouse and man. Proc Natl Acad Sci U S A. 2013; 110(21):8621-6. PMC: 3666675. DOI: 10.1073/pnas.1222722110. View

13.

Perkins J, Manning S, Tempero R, Cunningham M, Edmonds Jr J, Hoffer F . Lymphatic malformations: review of current treatment. Otolaryngol Head Neck Surg. 2010; 142(6):795-803, 803.e1. DOI: 10.1016/j.otohns.2010.02.026. View

14.

Sharma D, Lamba S, Pandita A, Shastri S . Klippel-trénaunay syndrome - a very rare and interesting syndrome. Clin Med Insights Circ Respir Pulm Med. 2015; 9:1-4. PMC: 4356473. DOI: 10.4137/CCRPM.S21645. View

15.

Rasmussen J, Kwon S, Sevick-Muraca E, Cormier J . The role of lymphatics in cancer as assessed by near-infrared fluorescence imaging. Ann Biomed Eng. 2011; 40(2):408-21. PMC: 3288459. DOI: 10.1007/s10439-011-0476-1. View