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Excitatory Aminoacid Antagonists Provide a Therapeutic Approach to Neurological Disorders

Overview
Journal Lancet
Publisher Elsevier
Specialty General Medicine
Date 1985 Jul 20
PMID 2862329
Citations 30
Authors
Affiliations
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Abstract

Excessive excitation by neurotransmitters can cause the death of neurons. This excitotoxic action may be responsible for neuronal loss in stroke, cerebral palsy, epilepsy, ageing and Alzheimer's disease, Huntington's disease, and other chronic degenerative disorders. Compounds acting specifically to antagonise excitatory neurotransmission offer a novel therapeutic approach to these disorders.

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