Renal-Limited "Lupus-Like" Nephritis: How Much of a Lupus?

Overview

Journal Case Rep Nephrol Dial

Specialty Nephrology

Date 2017 Jun 15

PMID 28612005

Citations 4

Authors

Asmaa S Abu Maziad

Jose Torrealba

Mouin G Seikaly

Jared R Hassler

Allen R Hendricks

Affiliations

Soon will be listed here.

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by development of autoantibodies to nuclear and cytoplasmic antigens. A small subset of SLE patients who had the typical clinical features of SLE was reported to show persistently negative antinuclear antibody tests. Our report describes a 5-year-old male who presented with histopathological findings suggestive of lupus nephritis with no clinical signs or symptoms of SLE and negative autoantibodies. He was treated with corticosteroids, mycophenolate mofetil, and monthly intravenous cyclophosphamide. During the 2-year follow-up period, the proteinuria resolved and kidney function improved with continued negative autoantibody workup. This case presents a category of renal-limited "lupus-like" glomerulonephritis which can be challenging to treat and carries a poor prognosis.

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