Cyclooxygenase 2 in Liver Dysfunction and Carcinogenesis: Facts and Perspectives

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2017 Jun 15

PMID 28611510

Citations 13

Authors

Paloma Martin-Sanz

Marta Casado

Lisardo Bosca

Affiliations

Soon will be listed here.

Abstract

The biosynthesis of prostaglandins and thromboxanes has been a focus of interest in the management of many liver diseases. Cyclooxygenases are the enzymes involved in the first step of the biosynthesis of these lipid mediators and selective inhibitors for these isoenzymes as well as pharmacological analogues of prostaglandins have been developed and are currently applied therapeutically. Here we discuss the implications of these enzymes in the onset of metabolic and lipid disorders in the liver and their potential role in the progression of the diseases towards fibrosis and hepatocellular carcinogenesis.

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