High-sensitivity Cardiac Troponin T is a Biomarker for Atherosclerosis in Systemic Lupus Erythematous Patients: a Cross-sectional Controlled Study

Overview

Journal Arthritis Res Ther

Publisher Biomed Central

Specialty Rheumatology

Date 2017 Jun 15

PMID 28610589

Citations 9

Authors

Gillian Divard

Rachid Abbas

Camille Chenevier-Gobeaux

Noemie Chanson

Brigitte Escoubet

Marie-Paule Chauveheid

Antoine Dossier

Thomas Papo

Monique Dehoux

Karim Sacre

Affiliations

Soon will be listed here.

Abstract

Background: Cardiovascular disease (CVD) is the main cause of death in systemic lupus erythematous (SLE) patients. The Framingham score underestimates the risk for CVD in this population. Our study aimed to determine whether serum high-sensitivity cardiac troponin T (HS-cTnT) might help to identify SLE patients at risk for CVD.

Methods: The presence of carotid plaques was prospectively assessed by ultrasound in 63 consecutive SLE patients asymptomatic for CVD and 18 controls. Serum HS-cTnT concentration was measured using the electrochemiluminescence method. Factors associated with carotid plaques were identified and multivariate analysis was performed.

Results: Framingham score was low in both SLE patients (median 1 (range 1-18%)) and controls (1 (1-13%)). Nevertheless, 23 (36.5%) SLE patients, but only 2 (11.1%) controls (p = 0.039), had carotid plaque detected by vascular ultrasound. In the multivariate analysis, only age (p = 0.006) and SLE status (p = 0.017) were independently associated with carotid plaques. Serum HS-cTnT concentration was detectable (i.e. >3 ng/L) in 37 (58.7%) SLE patients and 6 (33.3%) controls (p = 0.057). Interestingly, 87% of SLE patients with carotid plaques, but only 42.5% of SLE patients without plaques (p < 0.001), had detectable HS-cTnT. Conversely, 54.5% of SLE patients with detectable HS-cTnT, but only 11.5% with undetectable HS-cTnT (p < 0.001), had a carotid plaque. In the multivariate analysis, only body mass index (p = 0.006) and HS-cTnT (p = 0.033) were statistically associated with carotid plaques in SLE patients. Overall, the risk of having a carotid plaque was increased by 9 (odds ratio 9.26, 95% confidence interval 1.55-90.07) in SLE patients in whom HS-cTnT was detectable in serum.

Conclusion: Serum HS-cTnT level is high and associated with carotid plaques in SLE patients who are at an apparently low risk for CVD according to the Framingham score. HS-cTnT may be a useful biomarker for SLE-associated atherosclerosis.

Citing Articles

Advanced Parameters of Myocardial Strain and Cardiac Biomarkers Indicate Subclinical Systolic Myocardial Dysfunction in Patients with Systemic Lupus Erythematous.

Kadoglou N, Dimopoulou A, Korakianitis I, Parperis K Biomedicines. 2024; 12(11).

PMID: 39595202 PMC: 11592096. DOI: 10.3390/biomedicines12112638.

Altered Arterial Stiffness, Ventricular-Arterial Coupling and Troponin Levels in Patients with Systemic Lupus Erythematosus.

Kadoglou N, Dimopoulou A, Gkougkoudi E, Parperis K Medicina (Kaunas). 2024; 60(5).

PMID: 38793004 PMC: 11122872. DOI: 10.3390/medicina60050821.

Assessment of Arterial Stiffness and Biochemical Markers in Systemic Lupus Erythematosus in the Diagnosis of Subclinical Atherosclerosis.

Blachut D, Przywara-Chowaniec B, Mazurkiewicz M, Tomasik A J Pers Med. 2024; 14(3).

PMID: 38541031 PMC: 10971100. DOI: 10.3390/jpm14030289.

Update of Potential Biomarkers in Risk Prediction and Monitoring of Atherosclerosis in Systemic Lupus Erythematosus to Prevent Cardiovascular Disease.

Blachut D, Przywara-Chowaniec B, Tomasik A, Kukulski T, Morawiec B Biomedicines. 2023; 11(10).

PMID: 37893187 PMC: 10604001. DOI: 10.3390/biomedicines11102814.

The use of high-sensitivity cardiac troponin I in assessing cardiac involvement and Disease prognosis in idiopathic inflammatory myopathy.

Zhang H, Chi H, Xie L, Sun Y, Liu H, Cheng X Adv Rheumatol. 2023; 63(1):52.

PMID: 37853434 DOI: 10.1186/s42358-023-00332-0.

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