Prematurity and Brain Perfusion: Arterial Spin Labeling MRI

Overview

Journal Neuroimage Clin

Publisher Elsevier

Specialties Neurology
Radiology

Date 2017 Jun 13

PMID 28603687

Citations 21

Authors

Domenico Tortora

Peter Angelo Mattei

Riccardo Navarra

Valentina Panara

Rita Salomone

Andrea Rossi

John A Detre

Massimo Caulo

Affiliations

Soon will be listed here.

Abstract

Purpose: Abnormal brain perfusion is a critical mechanism in neonatal brain injury. The aim of the present study was to compare Cerebral Blood Flow (CBF) evaluated with ASL MRI in three groups of neonates: preterms without brain lesions on MRI (PN), preterms with periventricular white matter lesions (PNp) and term neonates with normal MRI (TN). The correlation between CBF and clinical outcome was explored.

Materials And Methods: The institutional review board approved this prospective study and waived informed consent. The perfusion ASL data from 49 consecutive preterm neonates (PN) studied at term-equivalent age and 15 TN were evaluated. Statistically significant differences in gray matter CBF were evaluated by using a linear mixed-model analysis and Mann-Whitney test. Logistic regression analysis was used to assess the relation between CBF and neuromotor outcome at 12 months.

Results: Comparison of means indicated that the CBF of the whole brain were significantly higher in PN compared to TN ( = 0.011). This difference remained significant when considering the frontal ( = 0.038), parietal ( = 0.002), temporal ( = 0.030), occipital ( = 0.041) and cerebellar ( = 0.010) gray matter. In the PN group, lower CBF in basal ganglia was associated with a worse neuromotor outcome ( = 0.012).

Conclusions: ASL MRI demonstrated differences in brain perfusion of the basal ganglia between PN and TN. In PN, a positive correlation between CBF and neuromotor outcome was demonstrated in this area.

Citing Articles

White Matter Injury in Central Nervous System Disorders.

Zheng L, Wang X, Li P, Hao Y, Zhang H, Chen H Neuropsychiatr Dis Treat. 2025; 21:107-114.

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Evaluation of the effect of intraventricular haemorrhage on cerebral perfusion in preterm neonates using three-dimensional pseudo-continuous arterial spin labelling.

Qin C, Zhao X, Shen Y, Lu Y, Li S, Zhang C Pediatr Radiol. 2024; 54(5):776-786.

PMID: 38321237 DOI: 10.1007/s00247-024-05865-0.

Cerebral blood flow patterns in preterm and term neonates assessed with pseudo-continuous arterial spin labeling perfusion MRI.

Piccirilli E, Chiarelli A, Sestieri C, Mascali D, Calvo Garcia D, Primavera A Hum Brain Mapp. 2023; 44(9):3833-3844.

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Measuring Quantitative Cerebral Blood Flow in Healthy Children: A Systematic Review of Neuroimaging Techniques.

Zhao M, Tong E, Duarte Armindo R, Woodward A, Yeom K, Moseley M J Magn Reson Imaging. 2023; 59(1):70-81.

PMID: 37170640 PMC: 10638464. DOI: 10.1002/jmri.28758.

Current state and guidance on arterial spin labeling perfusion MRI in clinical neuroimaging.

Lindner T, Bolar D, Achten E, Barkhof F, Bastos-Leite A, Detre J Magn Reson Med. 2023; 89(5):2024-2047.

PMID: 36695294 PMC: 10914350. DOI: 10.1002/mrm.29572.

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