Vaccination of Rabbits Against Entamoeba Histolytica with Aqueous Suspensions of Trehalose-dimycolate As the Adjuvant

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1985 Jun 1

PMID 2860068

Citations 5

Authors

A Sharma

A Haq

S Ahmad

E Lederer

Affiliations

Soon will be listed here.

Abstract

Rabbits were immunized with soluble Entamoeba histolytica antigen with an aqueous suspension of trehalose-6,6'-dimycolate used as the adjuvant. Induction of protective immunity in the immunized animals was demonstrated by enhanced humoral and cell-mediated immune responses and 100% survival after challenge. Administration of soluble antigen only failed to induce a similar degree of protective immunity. Trehalose-6,6'-dimycolate alone produced only a slight increase in nonspecific resistance.

Citing Articles

Protection of gerbils from amebic liver abscess by immunization with a recombinant protein derived from the 170-kilodalton surface adhesin of Entamoeba histolytica.

Zhang T, Stanley Jr S Infect Immun. 1994; 62(6):2605-8.

PMID: 8188384 PMC: 186551. DOI: 10.1128/iai.62.6.2605-2608.1994.

Protection of gerbils from amebic liver abscess by immunization with a recombinant Entamoeba histolytica antigen.

Zhang T, Cieslak P, Stanley Jr S Infect Immun. 1994; 62(4):1166-70.

PMID: 8132322 PMC: 186248. DOI: 10.1128/iai.62.4.1166-1170.1994.

Isolation of the galactose-binding lectin that mediates the in vitro adherence of Entamoeba histolytica.

Petri Jr W, Smith R, Schlesinger P, Murphy C, Ravdin J J Clin Invest. 1987; 80(5):1238-44.

PMID: 2890654 PMC: 442376. DOI: 10.1172/JCI113198.

Adjuvant effects of trehalose dimycolate on the antibody response to type III pneumococcal polysaccharide.

Baker P, Fauntleroy M, STASHAK P, Hiernaux J, Cantrell J, Rudbach J Infect Immun. 1989; 57(3):912-7.

PMID: 2783922 PMC: 313198. DOI: 10.1128/iai.57.3.912-917.1989.

Protection of gerbils from amebic liver abscess by immunization with the galactose-specific adherence lectin of Entamoeba histolytica.

Petri Jr W, Ravdin J Infect Immun. 1991; 59(1):97-101.

PMID: 1987067 PMC: 257710. DOI: 10.1128/iai.59.1.97-101.1991.

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