» Articles » PMID: 2860005

Pituitary Growth Hormone and Hypothalamic Somatostatin in Young Female Rats Versus Old Constant Estrous Female Rats

Overview
Journal Experientia
Specialty Science
Date 1985 May 15
PMID 2860005
Citations 6
Authors
Affiliations
Soon will be listed here.
Abstract

Pituitary content and concentration of growth hormone was significantly reduced, and hypothalamic somatostatin content significantly increased, in old constant estrous as compared to young female rats. Increased levels of somatostatin may contribute to the decrease in pituitary growth hormone levels in these animals.

Citing Articles

Neuroendocrine-immune correlates of circadian physiology: studies in experimental models of arthritis, ethanol feeding, aging, social isolation, and calorie restriction.

Esquifino A, Cano P, Jimenez-Ortega V, Fernandez-Mateos P, Cardinali D Endocrine. 2007; 32(1):1-19.

PMID: 17992597 DOI: 10.1007/s12020-007-9009-y.


Dehydroepiandrosterone restoration of growth hormone gene expression in aging female rats, in vivo and in vitro: evidence for actions via estrogen receptors.

Iruthayanathan M, Zhou Y, Childs G Endocrinology. 2005; 146(12):5176-87.

PMID: 16150906 PMC: 1868401. DOI: 10.1210/en.2005-0811.


Interactive regulation of postmenopausal growth hormone insulin-like growth factor axis by estrogen and growth hormone-releasing peptide-2.

Veldhuis J, Evans W, Bowers C, Anderson S Endocrine. 2001; 14(1):45-62.

PMID: 11322501 DOI: 10.1385/ENDO:14:1:045.


Mechanisms of age-related endocrine alterations. Part II.

Mooradian A Drugs Aging. 1993; 3(2):131-46.

PMID: 8386570 DOI: 10.2165/00002512-199303020-00004.


The effect of aging on fracture healing in the rat.

Bak B, Andreassen T Calcif Tissue Int. 1989; 45(5):292-7.

PMID: 2509018 DOI: 10.1007/BF02556022.


References
1.
Eden S, Albertsson-Wikland K, Isaksson O . Plasma levels of growth hormone in female rats of different ages. Acta Endocrinol (Copenh). 1978; 88(4):676-90. DOI: 10.1530/acta.0.0880676. View

2.
FLORINI J, Harned J, Richman R, Weiss J . Effect of rat age on serum levels of growth hormone and somatomedins. Mech Ageing Dev. 1981; 15(2):165-76. DOI: 10.1016/0047-6374(81)90072-5. View

3.
Lu J, Damassa D, Gilman D, Judd H, SAWYER C . Differential patterns of gonadotropin responses to ovarian steroids and to LH-releasing hormone between constant-estrous and pseudopregnant states in aging rats. Biol Reprod. 1980; 23(2):345-51. DOI: 10.1095/biolreprod23.2.345. View

4.
Sonntag W, Steger R, Forman L, Meites J . Decreased pulsatile release of growth hormone in old male rats. Endocrinology. 1980; 107(6):1875-9. DOI: 10.1210/endo-107-6-1875. View

5.
Kasting N, Martin J, Arnold M . Pulsatile somatostatin release from the median eminence of the unanesthetized rat and its relationship to plasma growth hormone levels. Endocrinology. 1981; 109(5):1739-45. DOI: 10.1210/endo-109-5-1739. View