Conserved Signaling Mechanisms in Drosophila Heart Development

Overview

Journal Dev Dyn

Publisher Wiley

Specialty Anatomy & Histology

Date 2017 Jun 10

PMID 28598558

Citations 22

Authors

Shaad M Ahmad

Affiliations

Soon will be listed here.

Abstract

Signal transduction through multiple distinct pathways regulates and orchestrates the numerous biological processes comprising heart development. This review outlines the roles of the FGFR, EGFR, Wnt, BMP, Notch, Hedgehog, Slit/Robo, and other signaling pathways during four sequential phases of Drosophila cardiogenesis-mesoderm migration, cardiac mesoderm establishment, differentiation of the cardiac mesoderm into distinct cardiac cell types, and morphogenesis of the heart and its lumen based on the proper positioning and cell shape changes of these differentiated cardiac cells-and illustrates how these same cardiogenic roles are conserved in vertebrates. Mechanisms bringing about the regulation and combinatorial integration of these diverse signaling pathways in Drosophila are also described. This synopsis of our present state of knowledge of conserved signaling pathways in Drosophila cardiogenesis and the means by which it was acquired should facilitate our understanding of and investigations into related processes in vertebrates. Developmental Dynamics 246:641-656, 2017. © 2017 Wiley Periodicals, Inc.

Citing Articles

Genome-Wide Expression Profiling and Phenotypic Analysis of Downstream Targets Identify the Fox Transcription Factor Jumeau as a Master Regulator of Cardiac Progenitor Cell Division.

Hasan M, Kump A, Stepaniak E, Panta M, Shashidhar K, Katariya R Int J Mol Sci. 2024; 25(23).

PMID: 39684645 PMC: 11641245. DOI: 10.3390/ijms252312933.

Distinct roles of COMPASS subunits to Drosophila heart development.

Zhu J, van de Leemput J, Han Z Biol Open. 2024; 13(10).

PMID: 39417277 PMC: 11554255. DOI: 10.1242/bio.061736.

The Enigmas of Tissue Closure: Inspiration from .

Huang X, Su Z, Xie X Curr Issues Mol Biol. 2024; 46(8):8710-8725.

PMID: 39194731 PMC: 11352826. DOI: 10.3390/cimb46080514.

Molecular regulators of defective placental and cardiovascular development in fetal growth restriction.

Umapathy A, Clark A, Sehgal A, Karanam V, Rajaraman G, Kalionis B Clin Sci (Lond). 2024; 138(13):761-775.

PMID: 38904187 PMC: 11193155. DOI: 10.1042/CS20220428.

Drosophila as a Model to Understand Second Heart Field Development.

Bileckyj C, Blotz B, M Cripps R J Cardiovasc Dev Dis. 2023; 10(12).

PMID: 38132661 PMC: 10744189. DOI: 10.3390/jcdd10120494.

References

Eisenberg C, Eisenberg L . WNT11 promotes cardiac tissue formation of early mesoderm. Dev Dyn. 1999; 216(1):45-58. DOI: 10.1002/(SICI)1097-0177(199909)216:1<45::AID-DVDY7>3.0.CO;2-L. View

Chen C, Struhl G . Wingless transduction by the Frizzled and Frizzled2 proteins of Drosophila. Development. 1999; 126(23):5441-52. DOI: 10.1242/dev.126.23.5441. View

Han Z, Bodmer R . Myogenic cells fates are antagonized by Notch only in asymmetric lineages of the Drosophila heart, with or without cell division. Development. 2003; 130(13):3039-51. DOI: 10.1242/dev.00484. View

Boettger T, Wittler L, Kessel M . FGF8 functions in the specification of the right body side of the chick. Curr Biol. 1999; 9(5):277-80. DOI: 10.1016/s0960-9822(99)80119-5. View

MICHELSON A, Gisselbrecht S, Zhou Y, Baek K, Buff E . Dual functions of the heartless fibroblast growth factor receptor in development of the Drosophila embryonic mesoderm. Dev Genet. 1998; 22(3):212-29. DOI: 10.1002/(SICI)1520-6408(1998)22:3<212::AID-DVG4>3.0.CO;2-9. View

Yin Z, Frasch M . Regulation and function of tinman during dorsal mesoderm induction and heart specification in Drosophila. Dev Genet. 1998; 22(3):187-200. DOI: 10.1002/(SICI)1520-6408(1998)22:3<187::AID-DVG2>3.0.CO;2-2. View

Go A, Mozaffarian D, Roger V, Benjamin E, Berry J, Blaha M . Executive summary: heart disease and stroke statistics--2014 update: a report from the American Heart Association. Circulation. 2014; 129(3):399-410. DOI: 10.1161/01.cir.0000442015.53336.12. View

Ma L, Lu M, Schwartz R, Martin J . Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning. Development. 2005; 132(24):5601-11. DOI: 10.1242/dev.02156. View

Digilio M, Marino B . What Is New in Genetics of Congenital Heart Defects?. Front Pediatr. 2016; 4:120. PMC: 5130977. DOI: 10.3389/fped.2016.00120. View

10.

Silva R, DAmico G, Hodivala-Dilke K, Reynolds L . Integrins: the keys to unlocking angiogenesis. Arterioscler Thromb Vasc Biol. 2008; 28(10):1703-13. DOI: 10.1161/ATVBAHA.108.172015. View

11.

Zhang H, Bradley A . Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development. Development. 1996; 122(10):2977-86. DOI: 10.1242/dev.122.10.2977. View

12.

Ilagan R, Abu-Issa R, Brown D, Yang Y, Jiao K, Schwartz R . Fgf8 is required for anterior heart field development. Development. 2006; 133(12):2435-45. DOI: 10.1242/dev.02408. View

13.

Parker D, Jemison J, Cadigan K . Pygopus, a nuclear PHD-finger protein required for Wingless signaling in Drosophila. Development. 2002; 129(11):2565-76. DOI: 10.1242/dev.129.11.2565. View

14.

Liu J, Qian L, Wessells R, Bidet Y, Jagla K, Bodmer R . Hedgehog and RAS pathways cooperate in the anterior-posterior specification and positioning of cardiac progenitor cells. Dev Biol. 2006; 290(2):373-85. DOI: 10.1016/j.ydbio.2005.11.033. View

15.

Bodmer R, Jan L, Jan Y . A new homeobox-containing gene, msh-2, is transiently expressed early during mesoderm formation of Drosophila. Development. 1990; 110(3):661-9. DOI: 10.1242/dev.110.3.661. View

16.

Hurlstone A, Haramis A, Wienholds E, Begthel H, Korving J, van Eeden F . The Wnt/beta-catenin pathway regulates cardiac valve formation. Nature. 2003; 425(6958):633-7. DOI: 10.1038/nature02028. View

17.

Tsiairis C, McMahon A . An Hh-dependent pathway in lateral plate mesoderm enables the generation of left/right asymmetry. Curr Biol. 2009; 19(22):1912-7. PMC: 2787870. DOI: 10.1016/j.cub.2009.09.057. View

18.

Jagla K, Frasch M, Jagla T, Dretzen G, Bellard F, BELLARD M . ladybird, a new component of the cardiogenic pathway in Drosophila required for diversification of heart precursors. Development. 1997; 124(18):3471-9. DOI: 10.1242/dev.124.18.3471. View

19.

Lindsley R, Gill J, Kyba M, Murphy T, Murphy K . Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm. Development. 2006; 133(19):3787-96. DOI: 10.1242/dev.02551. View

20.

Lough J, Barron M, Brogley M, Sugi Y, Bolender D, Zhu X . Combined BMP-2 and FGF-4, but neither factor alone, induces cardiogenesis in non-precardiac embryonic mesoderm. Dev Biol. 1996; 178(1):198-202. DOI: 10.1006/dbio.1996.0211. View