Genome-wide Approach Identifies a Novel Gene-maternal Pre-pregnancy BMI Interaction on Preterm Birth

Overview

Journal Nat Commun

Specialty Biology

Date 2017 Jun 10

PMID 28598419

Citations 27

Authors

Xiumei Hong

Ke Hao

Hongkai Ji

Shouneng Peng

Ben Sherwood

Antonio Di Narzo

Hui-Ju Tsai

Xin Liu

Irina Burd

Guoying Wang

Yuelong Ji

Deanna Caruso

Guangyun Mao

Tami R Bartell

Zhongyang Zhang

Colleen Pearson

Linda Heffner

Sandra Cerda

Terri H Beaty

M Daniele Fallin

Aviva Lee-Parritz

Barry Zuckerman

Daniel E Weeks

Xiaobin Wang

Affiliations

Soon will be listed here.

Abstract

Preterm birth (PTB) contributes significantly to infant mortality and morbidity with lifelong impact. Few robust genetic factors of PTB have been identified. Such 'missing heritability' may be partly due to gene × environment interactions (G × E), which is largely unexplored. Here we conduct genome-wide G × E analyses of PTB in 1,733 African-American women (698 mothers of PTB; 1,035 of term birth) from the Boston Birth Cohort. We show that maternal COL24A1 variants have a significant genome-wide interaction with maternal pre-pregnancy overweight/obesity on PTB risk, with rs11161721 (P=1.8 × 10; empirical P=1.2 × 10) as the top hit. This interaction is replicated in African-American mothers (P=0.01) from an independent cohort and in meta-analysis (P=3.6 × 10), but is not replicated in Caucasians. In adipose tissue, rs11161721 is significantly associated with altered COL24A1 expression. Our findings may provide new insight into the aetiology of PTB and improve our ability to predict and prevent PTB.

Citing Articles

Newborn DNA methylation age differentiates long-term weight trajectories: the Boston Birth Cohort.

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Recent Advances in Genomic Studies of Gestational Duration and Preterm Birth.

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Equitable Representation of Race, Ethnicity, and Ancestry Among Genomic Studies of Preterm Birth: A Systematic Review.

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Integrative analysis of noncoding mutations identifies the druggable genome in preterm birth.

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Genetic association study of Preterm birth and Gestational age in a population-based case-control study in Peru: Genetics of PTB and GA in pregnant women in Peru.

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