Heparin-Induced Thrombocytopenia in Cardiac Surgery Patients

Overview

Journal Semin Thromb Hemost

Publisher Thieme

Specialties Cardiology & Vascular Diseases
Hematology

Date 2017 Jun 10

PMID 28597462

Citations 13

Authors

Allyson M Pishko

Adam Cuker

Affiliations

Soon will be listed here.

Citing Articles

Long-term outcomes of heparin-induced thrombocytopenia after cardiac surgery.

Rodriguez E, Daskam M, Shou B, Woodrum C, Gupta R, Dane K JTCVS Open. 2025; 23:190-198.

PMID: 40061541 PMC: 11883693. DOI: 10.1016/j.xjon.2024.10.029.

Risk factors and prediction model for thrombocytopenia following coronary artery bypass graft surgery in elderly Chinese population.

Zhao H, Zhang W, Liu Y, Peng W J Thorac Dis. 2024; 16(1):273-284.

PMID: 38410552 PMC: 10894372. DOI: 10.21037/jtd-23-1396.

Heparin-induced thrombocytopenia: An illustrated review.

May J, Westbrook B, Cuker A Res Pract Thromb Haemost. 2023; 7(5):100283.

PMID: 37601013 PMC: 10439402. DOI: 10.1016/j.rpth.2023.100283.

Evaluation of Latex Immunoturbidimetric Assay Thresholds and HIT in Cardiothoracic Surgery.

Hernandez J, Patel H, Biddlecome P, Kildea M, Dwivedi R, Sridhara S Clin Appl Thromb Hemost. 2023; 29:10760296231166370.

PMID: 37069794 PMC: 10123911. DOI: 10.1177/10760296231166370.

Cardiopulmonary Bypass Surgery in a Patient with Unexpected Heparin-Induced Thrombocytopenia.

Miyagawa A, Yuri K, Nakano M, Shinoda D, Makino J Ann Vasc Dis. 2023; 15(4):352-355.

PMID: 36644263 PMC: 9816026. DOI: 10.3400/avd.cr.22-00082.

References

Selleng S, Malowsky B, Strobel U, Wessel A, Ittermann T, Wollert H . Early-onset and persisting thrombocytopenia in post-cardiac surgery patients is rarely due to heparin-induced thrombocytopenia, even when antibody tests are positive. J Thromb Haemost. 2009; 8(1):30-6. DOI: 10.1111/j.1538-7836.2009.03626.x. View

Warkentin T, Kelton J . Temporal aspects of heparin-induced thrombocytopenia. N Engl J Med. 2001; 344(17):1286-92. DOI: 10.1056/NEJM200104263441704. View

Sun L, Gimotty P, Lakshmanan S, Cuker A . Diagnostic accuracy of rapid immunoassays for heparin-induced thrombocytopenia. A systematic review and meta-analysis. Thromb Haemost. 2016; 115(5):1044-55. DOI: 10.1160/TH15-06-0523. View

WALLIS D, Lewis B, Walenga J . Failure of current strategies in the prevention of thrombosis in patients with heparin-induced thrombocytopenia: a clinician's perspective. Semin Thromb Hemost. 1999; 25 Suppl 1:3-7. View

Rauova L, Poncz M, McKenzie S, Reilly M, Arepally G, Weisel J . Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia. Blood. 2004; 105(1):131-8. DOI: 10.1182/blood-2004-04-1544. View

Bakchoul T, Zollner H, Amiral J, Panzer S, Selleng S, Kohlmann T . Anti-protamine-heparin antibodies: incidence, clinical relevance, and pathogenesis. Blood. 2013; 121(15):2821-7. DOI: 10.1182/blood-2012-10-460691. View

Welsby I, Krakow E, Heit J, Williams E, Arepally G, Bar-Yosef S . The association of anti-platelet factor 4/heparin antibodies with early and delayed thromboembolism after cardiac surgery. J Thromb Haemost. 2016; 15(1):57-65. PMC: 5280211. DOI: 10.1111/jth.13533. View

Watson H, Davidson S, Keeling D . Guidelines on the diagnosis and management of heparin-induced thrombocytopenia: second edition. Br J Haematol. 2012; 159(5):528-40. DOI: 10.1111/bjh.12059. View

Denys B, Stove V, Philippe J, Devreese K . A clinical-laboratory approach contributing to a rapid and reliable diagnosis of heparin-induced thrombocytopenia. Thromb Res. 2008; 123(1):137-45. DOI: 10.1016/j.thromres.2008.04.020. View

10.

Everett B, Yeh R, Foo S, Criss D, Van Cott E, Laposata M . Prevalence of heparin/platelet factor 4 antibodies before and after cardiac surgery. Ann Thorac Surg. 2007; 83(2):592-7. DOI: 10.1016/j.athoracsur.2006.09.040. View

11.

Amiral J, Bridey F, Dreyfus M, Vissoc A, Fressinaud E, Wolf M . Platelet factor 4 complexed to heparin is the target for antibodies generated in heparin-induced thrombocytopenia. Thromb Haemost. 1992; 68(1):95-6. View

12.

Lee G, Welsby I, Phillips-Bute B, Ortel T, Arepally G . High incidence of antibodies to protamine and protamine/heparin complexes in patients undergoing cardiopulmonary bypass. Blood. 2013; 121(15):2828-35. PMC: 3624931. DOI: 10.1182/blood-2012-11-469130. View

13.

Hassan S, Qureshi W, Badami A, Khoulani D, Mittal C, Amer S . Heparin-induced thrombocytopenia: is it a graft-threatening complication?. Transpl Int. 2013; 26(4):385-91. DOI: 10.1111/tri.12051. View

14.

Cuker A . Current and emerging therapeutics for heparin-induced thrombocytopenia. Semin Thromb Hemost. 2012; 38(1):31-7. DOI: 10.1055/s-0031-1300949. View

15.

Cuker A, Cines D . Protamine-induced thrombocytopenia?. Blood. 2013; 121(15):2818-9. DOI: 10.1182/blood-2013-02-480467. View

16.

Bauer T, Arepally G, Konkle B, Mestichelli B, Shapiro S, Cines D . Prevalence of heparin-associated antibodies without thrombosis in patients undergoing cardiopulmonary bypass surgery. Circulation. 1997; 95(5):1242-6. DOI: 10.1161/01.cir.95.5.1242. View

17.

Matthai Jr W . Thrombocytopenia in cardiovascular patients: diagnosis and management. Chest. 2005; 127(2 Suppl):46S-52S. DOI: 10.1378/chest.127.2_suppl.46S. View

18.

Pouplard C, Leroux D, Rollin J, Amiral J, May M, Gruel Y . Incidence of antibodies to protamine sulfate/heparin complexes incardiac surgery patients and impact on platelet activation and clinical outcome. Thromb Haemost. 2013; 109(6):1141-7. DOI: 10.1160/TH12-11-0844. View

19.

Berry C, Tcherniantchouk O, Ley E, Salim A, Mirocha J, Martin-Stone S . Overdiagnosis of heparin-induced thrombocytopenia in surgical ICU patients. J Am Coll Surg. 2011; 213(1):10-7. DOI: 10.1016/j.jamcollsurg.2011.04.002. View

20.

Vonderheide R, Thadhani R, Kuter D . Association of thrombocytopenia with the use of intra-aortic balloon pumps. Am J Med. 1998; 105(1):27-32. DOI: 10.1016/s0002-9343(98)00128-4. View