Bacteremia During Early Post-allogeneic Hematopoietic Stem Cell Transplantation Period: A Single Center Experience

Overview

Journal Indian J Hematol Blood Transfus

Specialty Hematology

Date 2017 Jun 10

PMID 28596651

Citations 3

Authors

Amro Mohamed Sedky El-Ghammaz

Affiliations

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Abstract

Bacteremia is a significant complication of allogeneic hematopoietic stem cell transplantation (HSCT). We aimed to study bacteremia occurring during early post-transplant period at Bone Marrow Transplantation Unit of Ain Shams University regarding its risk factors and impact on survival. Patients performing allogeneic HSCT were followed up for occurrence of bacteremia. Survival status was assessed at 180 days post-transplant. Bacteremia occurred in 53.3 % of patients. On univariate analysis, CD34 +ve cell dose ( = 0.004), duration of neutropenia ( = 0.018), time interval between day of stem cell infusion and day of neutrophil engraftment ( = 0.043) and > 1 apheresis days ( = 0.040) were associated with higher rates of bacteremia. On multivariate analysis, CD34 +ve cell dose ( = 0.002) and apheresis day number ( = 0.038) remained significant. There was significant difference between patients who developed bacteremia and those who did not regarding overall survival (OS) ( = 0.042). Patients developing bacteremia caused by Gram negative bacteria (GNB) had lower OS than Gram positive bacteria (GPB) ( < 0.001). In conclusion, stem cell dose and apheresis day number influence bacteremia risk. Also, Gram negative bacteremia has negative impact on allogeneic transplant recipient survival rates.

Citing Articles

Early bacteremia following allogeneic hematopoietic stem cell transplantation without antibiotic prophylaxis: epidemiology and antimicrobial resistance.

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Risk Factors for Neutropenic Sepsis Related Mortality in Children Undergoing Allogenic Hematopoietic Stem Cell Transplantation.

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Bacteremia in Hematopoietic Stem Cell Recipients Receiving Fluoroquinolone Prophylaxis: Incidence, Resistance, and Risk Factors.

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Microbiology of Bloodstream Infections in Children After Hematopoietic Stem Cell Transplantation: A Single-Center Experience Over Two Decades (1997-2017).

Heston S, Young R, Hong H, Akinboyo I, Tanaka J, Martin P Open Forum Infect Dis. 2020; 7(11):ofaa465.

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