Meibomian Gland Dysfunction in Type 2 Diabetic Patients

Overview

Journal J Ophthalmol

Publisher Wiley

Specialty Ophthalmology

Date 2017 Jun 9

PMID 28593054

Citations 24

Authors

Xiaolei Lin

Binbin Xu

Yuxi Zheng

Terry G Coursey

Yinying Zhao

Junhua Li

Yana Fu

Xuewen Chen

Yun-E Zhao

Affiliations

Soon will be listed here.

Abstract

Purpose: To investigate meibomian gland and tear film function in patients with type 2 diabetes.

Methods: This prospective study compared changes in meibomian gland and tear film function in type 2 diabetic patients with nondiabetic patients. Meibomian gland function was evaluated by measuring lipid layer thickness (LLT), grading of meibomian gland loss, lid margin abnormalities, and expression of meibum. Tear film function was assessed by measuring tear breakup time (TBUT), the Schirmer I test, noninvasive breakup time (NIBUT), tear meniscus height (TMH), and corneal fluorescein staining.

Results: Meibography scores were significantly higher in the diabetic group compared with the nondiabetic group ( = 0.004). The number of expressible glands was significantly lower in the diabetic group in temporal, central, and nasal third of the lower eyelid (nasal: = 0.002; central: = 0.040; and temporal: = 0.039). The lid margin abnormality score was significantly higher in the diabetic group than in the nondiabetic group ( = 0.04). There was no statistically significant difference in the tear film function parameters between the two groups.

Conclusions: Meibomian gland dysfunction (MGD) in type 2 diabetic patients is more severe compared with nondiabetic patients. Overall, most of the diabetic patients manifest as having asymptomatic MGD.

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